coronary artery disease

[Journal of Cardiovascular Pharmacology] Researchers investigated the effect of circLDLR on the proliferation and apoptosis of vascular smooth muscle cells in coronary artery disease and its regulatory mechanism.

[Stem Cells Translational Medicine] The authors provide an update on the role of endothelial progenitor cells in the most common clinical scenarios that are experienced by cardiologists managing patients with coronary artery disease.

[Scientific Reports] Investigators characterized monocyte subsets in controls and disease phenotypes of coronary artery disease and mmyocardial infarction patients using flow cytometry and miRNA and mRNA expression profiling using RNA sequencing.

[Nature Communications] Using genetic analysis, human recall-by-genotype and in vitro experimentation, researchers demonstrated that PROCR-219Gly increased plasma levels of (activated) protein C through endothelial protein C receptor ectodomain shedding in endothelial cells, attenuating leukocyte–endothelial cell adhesion and vascular inflammation.

[Circulation Research] Mouse models of atherosclerosis in endothelial cell-specific-Bach1 knockout mice were used to study the role of BTB and CNC homology 1 (BACH1) in the regulation of atherogenesis and the underlying mechanisms.

[Cardiovascular Diabetology] Scientists analyzed endothelial microparticles with apoptotic characteristics and assessed the angiogenic contents of microparticles in the blood of patients with type 2 diabetes according to the presence of coronary artery disease.