Intracellular Ca2+ Dysregulation in Coronary Smooth Muscle Is Similar in Coronary Disease of Humans and Ossabaw Miniature Swine

Coronary smooth muscle (CSM) cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and metabolic syndrome swine with coronary artery disease. Similar [Ca2+]i dysregulation exhibited in human and Ossabaw swine CSM provides strong evidence for the translational relevance of this large animal model.
[Journal of Cardiovascular Translational Research]
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Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.
[Journal of Molecular and Cellular Cardiology]
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Association of Diet Quality with Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events

Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
[JAMA Cardiology]
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Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis

Researchers summarize technical and conceptual advancements derived from several publications that, collectively, illuminate new research directions to further explore the role of vascular smooth muscle cells in atherosclerotic disease.
[Circulation]
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CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis

Investigators showed that the CD200-CD200R pathway restrained activation of CD200R+ lesional macrophages, their production of CCR2 ligands, and monocyte recruitment in vitro and in vivo in an air pouch model.
[Circulation Research]
Kassiteridi Christina, Cole Jennifer E, Griseri Thibault, Falck-Hansen Mika, Goddard Michael E, Seneviratne Anusha N, Green Patricia Ann, Park Inhye, Shami Annelie, Pattarabanjird Tanyaporn, Upadhye Aditi, Taylor Angela M, Handa Ashok, Channon Keith M, Lutgens Esther, McNamara Coleen A, Williams Richard O, & Monaco Claudia. (n.d.). CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316062 Cite
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HeartFlow and MedAxiom Announce Collaboration to Improve Care Delivery for Patients with Coronary Artery Disease

HeartFlow, Inc. announced a collaboration to improve cardiovascular care for patients with coronary artery disease.
[HeartFlow, Inc. (BusinessWire, Inc.)]
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Ceramides and Other Sphingolipids as Drivers of Cardiovascular Disease

Scientists discuss the body of literature suggesting that ceramides are drivers — and not merely passengers — on the road to cardiovascular disease.
[Nature Reviews Cardiology]
Choi, R. H., Tatum, S. M., Symons, J. D., Summers, S. A., & Holland, W. L. (2021). Ceramides and other sphingolipids as drivers of cardiovascular disease. Nature Reviews Cardiology, 1–11. https://doi.org/10.1038/s41569-021-00536-1 Cite
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Caladrius Biosciences Treats First Patient in the Phase IIb FREEDOM Trial of CLBS16 for the Treatment of Coronary Microvascular Dysfunction

Caladrius Biosciences, Inc. announced that it has treated the first patient in its Phase IIb FREEDOM trial of CLBS16 as a therapy for coronary microvascular dysfunction at The Christ Hospital Health Network in Cincinnati, Ohio.
[Caladrius Biosciences, Inc.]
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Use of IL-23 Inhibitors for the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review

Scientists evaluate the efficacy and safety of IL-23 inhibitors in the treatment of plaque psoriasis and psoriatic arthritis.
[American Journal of Clinical Dermatology]
Yang, K., Oak, A. S. W., & Elewski, B. E. (2020). Use of IL-23 Inhibitors for the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review. American Journal of Clinical Dermatology. https://doi.org/10.1007/s40257-020-00578-0 Cite
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Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes

To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), scientists analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.
[Antioxidants]

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Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes

To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), the authors analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.
[Antioxidants]
Rodríguez-Sánchez, E., Navarro-García, J. A., González-Lafuente, L., Aceves-Ripoll, J., Vázquez-Sánchez, S., Poveda, J., Mercado-García, E., Corbacho-Alonso, N., Calvo-Bonacho, E., Fernández-Velasco, M., Álvarez-Llamas, G., Barderas, M. G., Ruilope, L. M., & Ruiz-Hurtado, G. (2020). Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes. Antioxidants, 9(12), 1213. https://doi.org/10.3390/antiox9121213 Cite
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