Coronary smooth muscle (CSM) cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and metabolic syndrome swine with coronary artery disease. Similar [Ca2+]i dysregulation exhibited in human and Ossabaw swine CSM provides strong evidence for the translational relevance of this large animal model.
[Journal of Cardiovascular Translational Research]
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Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.
[Journal of Molecular and Cellular Cardiology]
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Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
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Researchers summarize technical and conceptual advancements derived from several publications that, collectively, illuminate new research directions to further explore the role of vascular smooth muscle cells in atherosclerotic disease.
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Investigators showed that the CD200-CD200R pathway restrained activation of CD200R+ lesional macrophages, their production of CCR2 ligands, and monocyte recruitment in vitro and in vivo in an air pouch model.
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Kassiteridi Christina, Cole Jennifer E, Griseri Thibault, Falck-Hansen Mika, Goddard Michael E, Seneviratne Anusha N, Green Patricia Ann, Park Inhye, Shami Annelie, Pattarabanjird Tanyaporn, Upadhye Aditi, Taylor Angela M, Handa Ashok, Channon Keith M, Lutgens Esther, McNamara Coleen A, Williams Richard O, & Monaco Claudia. (n.d.). CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316062 Cite
HeartFlow, Inc. announced a collaboration to improve cardiovascular care for patients with coronary artery disease.
[HeartFlow, Inc. (BusinessWire, Inc.)]
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Scientists discuss the body of literature suggesting that ceramides are drivers — and not merely passengers — on the road to cardiovascular disease.
[Nature Reviews Cardiology]
Caladrius Biosciences, Inc. announced that it has treated the first patient in its Phase IIb FREEDOM trial of CLBS16 as a therapy for coronary microvascular dysfunction at The Christ Hospital Health Network in Cincinnati, Ohio.
[Caladrius Biosciences, Inc.]
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Scientists evaluate the efficacy and safety of IL-23 inhibitors in the treatment of plaque psoriasis and psoriatic arthritis.
[American Journal of Clinical Dermatology]
To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), scientists analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.
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To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), the authors analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.
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Rodríguez-Sánchez, E., Navarro-García, J. A., González-Lafuente, L., Aceves-Ripoll, J., Vázquez-Sánchez, S., Poveda, J., Mercado-García, E., Corbacho-Alonso, N., Calvo-Bonacho, E., Fernández-Velasco, M., Álvarez-Llamas, G., Barderas, M. G., Ruilope, L. M., & Ruiz-Hurtado, G. (2020). Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes. Antioxidants, 9(12), 1213. https://doi.org/10.3390/antiox9121213 Cite