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coronary artery disease

Therapeutic Potential of Colchicine in Cardiovascular Medicine: A Pharmacological Review

[Acta Pharmacologica Sinica] The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.

Adenoviral VEGF-B186R127S Gene Transfer Induces Angiogenesis and Improves Perfusion in Ischemic Heart

[iScience] Investigators cloned VEGF-B isoforms with different receptor binding profiles to clarify the roles of VEGFR-1 and Nrp-1 in angiogenesis and to see if angiogenic properties could be maintained while avoiding side effects.

Cardiovascular Systems, Inc. Announces First In-Human Experience with Coronary Everolimus Drug Coated Balloon

[Cardiovascular Systems, Inc. (BusinessWire, Inc.)] Cardiovascular Systems, Inc. (CSI®) (NASDAQ: CSII), a medical device company developing and commercializing innovative interventional treatment systems for patients with peripheral and coronary artery disease, announced today the start of enrollment in a first in-human trial of the coronary everolimus drug-coated balloon (DCB) being developed by Chansu Vascular Technologies, LLC (CVT).

Cardiac Toxicity from Bisphenol A Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

[Toxicology and Applied Pharmacology] Researchers found that bisphenol A (BPA) exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array

Intracellular Ca2+ Dysregulation in Coronary Smooth Muscle Is Similar in Coronary Disease of Humans and Ossabaw Miniature Swine

[Journal of Cardiovascular Translational Research] Coronary smooth muscle (CSM) cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and metabolic syndrome swine with coronary artery disease. Similar [Ca2+]i dysregulation exhibited in human and Ossabaw swine CSM provides strong evidence for the translational relevance of this large animal model.

Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

[Journal of Molecular and Cellular Cardiology] Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.

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