Administration of Aerosolized SARS-CoV-2 to K18-hACE2 Mice Uncouples Respiratory Infection from Fatal Neuroinvasion

Scientists described the use of an inhalation tower system that allowed exposure of unanesthetized mice to aerosolized virus under controlled conditions.
[Science Immunology]
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Functional Convalescent Plasma Antibodies and Pre-Infusion Titers Shape the Early Severe COVID-19 Immune Response

Investigators performed deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in convalescent plasma (CP) units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration.
[Nature Communications]
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Pfizer and BioNTech Receive Positive CHMP Opinion for COMIRNATY® in Children 5 to under 12 Years of Age in the European Union

Pfizer, Inc. announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency issued a positive opinion on the administration of the companies’ COVID-19 vaccine COMIRNATY® in children 5 to under 12 years of age.
[Pfizer, Inc.]
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Antibody Cocktail Effective against Variants of SARS-CoV-2

The authors analyzed the binding activity of six highly potent antibodies to the spike proteins of SARS-CoV-2 variants, assessed their neutralizing abilities with pseudovirus and authentic SARS-CoV-2 variants and evaluate efficacy of antibody cocktail in Delta SARS-CoV-2-infected hamster models as prophylactic and post-infection treatments.
[Journal of Biomedical Science]
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Modeling SARS-CoV-2 Propagation Using Rat Coronavirus-Associated Shedding and Transmission

Scientists used Sialodacryoadenitis Virus in rats to model the extent to which immune protection afforded by prior natural infection via high risk or low risk exposure, or by vaccination, influenced viral shedding and transmission on re-exposure.
[PLoS One]
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Severe Neonatal COVID-19: Challenges in Management and Therapeutic Approach

The authors reported a severe case of neonatal COVID-19 requiring intensive care and mechanical ventilation, further complicated by a multidrug resistant Enterobacter asburiae super-infection.
[Journal of Medical Virology]
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Promising COVID-19 Therapeutic Drug to start Phase III Clinical Trial in the United States

Pulmonem, Inc. and the Research Institute of the McGill University Health Centre today announced that they have successfully started recruiting US-based patients for the Phase III Clinical Trial of the promising COVID-19 therapeutic drug PULM-001.
[Pulmonem, Inc.]
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ACE2-Like Carboxypeptidase B38-CAP Protects from SARS-CoV-2-Induced Lung Injury

Researchers showed that B38-CAP, an ACE2-like enzyme, was protective against SARS-CoV-2-induced lung injury.
[Nature Communications]
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Revive Therapeutics Files for FDA Orphan Drug Designation for Bucillamine in the Prevention of Ischemia-Reperfusion Injury during Liver Transplantation

Revive Therapeutics Ltd. announced that it has filed an application with the US FDA to receive Orphan Drug Designation for Bucillamine for the prevention of ischemia–reperfusion injury during liver transplantation.
[Revive Therapeutics Ltd.]
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Immune System Cells from COVID-19 Patients Display Compromised Mitochondrial-Nuclear Expression Co-Regulation and Rewiring towards Glycolysis

Analysis of eight single-cells RNA-seq datasets from peripheral blood mononuclear cells, nasopharyngeal samples and Broncho alveolar lavage fluid, revealed significantly reduced mtDNA gene expression especially in immune system cells from patients.
[iScience]
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Dexamethasone Modulates Immature Neutrophils and Interferon Programming in Severe COVID-19

Using single-cell RNA sequencing and plasma proteomics, scientists discovered that, compared to bacterial acute respiratory distress syndrom, COVID-19 was associated with the expansion of distinct neutrophil states characterized by interferon and prostaglandin signaling.
[Nature Medicine]
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