Progenitor Identification and SARS-CoV-2 Infection in Human Distal Lung Organoids

Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5+ basal cells.
[Nature]
Salahudeen, A. A., Choi, S. S., Rustagi, A., Zhu, J., van Unen, V., de la O, S. M., Flynn, R. A., Margalef-Català, M., Santos, A. J. M., Ju, J., Batish, A., Usui, T., Zheng, G. X. Y., Edwards, C. E., Wagar, L. E., Luca, V., Anchang, B., Nagendran, M., Nguyen, K., … Kuo, C. J. (2020). Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature, 1–9. https://doi.org/10.1038/s41586-020-3014-1 Cite
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AbCellera-Discovered Antibody Granted Interim Authorization by Health Canada as a Treatment for COVID-19

AbCellera announced that bamlanivimab 700 mg, a human antibody developed through AbCellera’s collaboration with Eli Lilly and Company, was granted authorization by Health Canada under the Interim Order Respecting the Importation, Sale and Advertising of Drugs for Use in Relation to COVID-19.
[AbCellera (BusinessWire, Inc.)]
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Bellerophon Therapeutics Announces Results of Interim Analysis of Phase III COViNOX Study of INOpulse® for the Treatment of COVID-19

Bellerophon Therapeutics, Inc. announced that the independent Data Monitoring Committee has completed its pre-specified interim analysis from the first 100 patients randomized in the Phase III COViNOX study of INOpulse® for the treatment of COVID-19.
[Bellerophon Therapeutics, Inc. (Globe Newswire, Inc.)]
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SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

Scientists assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic.
[Immunity]
SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors: Immunity. (n.d.). Retrieved November 24, 2020, from https://www.cell.com/immunity/fulltext/S1074-7613(20)30469-6 Cite
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Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

The authors performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived alveolar epithelial type 2 cells infected with SARS-CoV-2 at air-liquid interface.
[Molecular Cell]
Hekman, R. M., Hume, A. J., Goel, R. K., Abo, K. M., Huang, J., Blum, B. C., Werder, R. B., Suder, E. L., Paul, I., Phanse, S., Youssef, A., Alysandratos, K. D., Padhorny, D., Ojha, S., Mora-Martin, A., Kretov, D., Ash, P., Verma, M., Zhao, J., … Emili, A. (2020). Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.11.028 Cite
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Mesenchymal Stromal Cells for Acute Respiratory Distress Syndrome (ARDS), Sepsis and COVID 19 Infection: Optimising the Therapeutic Potential

The potential for MSC therapy in COVID-19 ARDS is discussed with insights from respiratory viral models and early clinical reports of MSC therapy in COVID-19.
[Expert Review of Respiratory Medicine]
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Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

The authors established a screening strategy to identify drugs that reduce angiotensin converting enzyme 2 levels in human ESC-derived cardiac cells and lung organoids.
[Cell Stem Cell]
Samuel, R. M., Majd, H., Richter, M. N., Ghazizadeh, Z., Zekavat, S. M., Navickas, A., Ramirez, J. T., Asgharian, H., Simoneau, C. R., Bonser, L. R., Koh, K. D., Garcia-Knight, M., Tassetto, M., Sunshine, S., Farahvashi, S., Kalantari, A., Liu, W., Andino, R., Zhao, H., … Fattahi, F. (2020). Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.11.009 Cite
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Thrombocytopathy and Endotheliopathy: Crucial Contributors to COVID-19 Thromboinflammation

The authors summarize new lines of evidence that point to both platelet and endothelial dysfunction as essential components of COVID-19 pathology and describe the mechanisms that might account for the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19.
[Nature Reviews Cardiology]
Gu, S. X., Tyagi, T., Jain, K., Gu, V. W., Lee, S. H., Hwa, J. M., Kwan, J. M., Krause, D. S., Lee, A. I., Halene, S., Martin, K. A., Chun, H. J., & Hwa, J. (2020). Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology, 1–16. https://doi.org/10.1038/s41569-020-00469-1 Cite
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Macrophage Expression and Prognostic Significance of the Long Pentraxin PTX3 in COVID-19

RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells expressed high levels of PTX3 in patients with COVID-19.
[Nature Immunology]
Brunetta, E., Folci, M., Bottazzi, B., De Santis, M., Gritti, G., Protti, A., Mapelli, S. N., Bonovas, S., Piovani, D., Leone, R., My, I., Zanon, V., Spata, G., Bacci, M., Supino, D., Carnevale, S., Sironi, M., Davoudian, S., Peano, C., … Mantovani, A. (2020). Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19. Nature Immunology, 1–6. https://doi.org/10.1038/s41590-020-00832-x Cite
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Texas Heart To Participate in Global Stem Cell Study to Treat ARDS due to COVID-19

The Texas Heart Institute has been selected as one of up to 60 sites in the world to participate in an international investigative study seeking to aid COVID-19 patients who develop acute respiratory distress syndrome (ARDS).
[Texas Heart Institute]
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Emergex Vaccines Raises US$11 million to Advance Pipeline of Synthetic T-Cell Vaccines for Infectious Diseases

Emergex Vaccines Holding Limited announced that it has raised $11 million in a funding round supported by new and existing investors.The proceeds of this funding round will enable Emergex to further advance and execute its vaccine development strategy, producing vaccine candidates for some of the world’s most threatening and virulent diseases such as COVID-19, Dengue Fever and pandemic flu.
[Emergex Vaccines Holding Limited (Globe Newswire, Inc.)]
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