COVID-19

[Blood] The authors address the vasculopathy of COVID-19 with a focus on the role of the endothelium in orchestrating the systemic response to SARS-CoV-2 infection.

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. announces receipt of guidance from the US FDA) for the further development of CDI-45205, Cocrystal’s novel SARS-CoV-2 main protease inhibitor as a potential treatment for COVID-19 and its variants via intranasal/pulmonary delivery.

[Advanced Science] A proteome map of COVID-19 skin was established and the susceptibility of human-induced pluripotent stem cell-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.

[Cell] Researchers identified highly activated, CD16+ T cells with increased cytotoxic functions in severe COVID-19.

[Science Translational Medicine] Scientists investigated the pharmacokinetics and efficacy of remdesivir administered by head dome inhalation in African green monkeys.

[Proceedings of the National Academy of Sciences of the United States of America] A strong response was induced in monocytes and B cells, with a SARS-CoV-2–specific inflammatory gene cluster distinct from that seen in influenza A or Ebola virus-infected cocultures, and which reproduced deviations reported in blood or lung myeloid cells from COVID-19 patients.