COVID-19

[Science Advances] Investigators found that triggering receptor expressed on myeloid cells 2 (TREM-2) was induced in T cells in the blood and lungs of patients with COVID-19.

[American Journal of Respiratory and Critical Care Medicine] Scientists describe alveolar and endothelial injury dynamics and associations with COVID-19 severity, cardiorenovascular injury, and outcomes.

[Proceedings of the National Academy of Sciences of the United States of America] The authors identified nonmuscle myosin heavy chain IIA as an important host factor for SARS-CoV-2 infection of human pulmonary cells by using APEX2 proximity-labeling techniques.

[Science Translational Medicine] Scientists evaluated longitudinal immune responses to two-dose BNT162b2 mRNA vaccination in 15 adults who had experienced COVID-19, compared to 21 adults who did not have prior COVID-19.

[NPJ Vaccines] To evaluate the yield and immunogenicity of different forms of the viral spike (S) protein, scientists constructed modified vaccinia virus Ankara (MVA) vectors expressing full-length S, the RBD, and soluble S ectodomain and tested their immunogenicity in dose-ranging studies in mice.

[Cell Reports Medicine] Scientists presented high-dimensional profiling of blood and respiratory samples in severe COVID-19 patients to examine the association between cell-linked molecular features and mortality outcomes.