It’s a Nightmare.’ How Brazilian Scientists Became Ensnared in Chloroquine Politics

In April, a published study showed chloroquine could increase mortality in COVID-19 patients. Since then, they have been accused of poisoning their patients with a high dose of chloroquine just to give the drug—praised by US President Donald Trump and his Brazilian counterpart Jair Bolsonaro—a bad name.
[ScienceInsider]
Press Release
Bookmark

No account yet? Register

0
Share

Top US Health Officials Say They Were Never Told to Slow Down COVID-19 Testing, Contradicting Trump

Four key government health care officials said Tuesday that despite recent remarks from President Trump, they were never ordered to “slow down” diagnostic testing for Covid-19.
[STAT News]
Press Release
Bookmark

No account yet? Register

0
Share

Drug Recently Shown to Reduce Coronavirus Death Risk Could Run Out, Experts Warn

A report that dexamethasone, a commonly used corticosteroid, reduces death rates of COVID-19 by up to one-third was greeted with enthusiasm around the globe. It also raised a question: Will there be enough of the medication?
[ScienceInsider]
Press Release
Bookmark

No account yet? Register

0
Share

Coronavirus Misinformation, and How Scientists Can Help to Fight It

Scientists are well placed to help to hold back the tide of COVID-19 misinformation — but should they get involved in time-consuming, and sometimes bruising, efforts to do so, or just stick to doing good research?
[Nature News]
Press Release
Bookmark

No account yet? Register

0
Share

Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections

Researchers studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 days and during hospitalization.
[Nature Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Researchers found that the monoclonal antibody CR3022 bound the receptor binding domain (RBD) tightly, neutralizing SARS-CoV-2 and report the crystal structure at 2.4 Å of the Fab/RBD complex.
[Cell Host & Microbe]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

COVID-19 Revisiting Inflammatory Pathways of Arthritis

The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
Full Article
Bookmark

No account yet? Register

0
Share

The Vascular Endothelium: The Cornerstone of Organ Dysfunction in Severe SARS-CoV-2 Infection

Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
[Critical Care]
Full Article
Bookmark

No account yet? Register

0
Share

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
Luo, W., Li, Y.-X., Jiang, L.-J., Chen, Q., Wang, T., & Ye, D.-W. (2020). Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.06.007 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Systemically Comparing Host Immunity between Survived and Deceased COVID-19 Patients

Scientists summarized the characteristics of cellular immune responses in a total of 157 COVID-19 patients enrolled in Tongji Hospital between February and March 2020 and compare the properties between 95 survived and 62 deceased patients with different onset time.
[Cellular & Molecular Immunology]
Full Article
Bookmark

No account yet? Register

0
Share

Optimization of Primer Sets and Detection Protocols for SARS-CoV-2 of Coronavirus Disease 2019 (COVID-19) Using PCR and Real-Time PCR

Scientists provide three-step guidelines for the design and optimization of specific primer sets. The three steps include the selection of primer sets for target genes in the genome of SARS-CoV-2, the in silico validation of primer and amplicon sequences, and the optimization of PCR conditions for specific hybridization between the primers and target genes, and the elimination of spurious primer dimers.
[Experimental and Molecular Medicine]
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR | Experimental & Molecular Medicine. (n.d.). Retrieved June 17, 2020, from https://www.nature.com/articles/s12276-020-0452-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share