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COVID-19

Interactions of Adenoviruses with Platelets and Coagulation and the Vaccine-Induced Immune Thrombotic Thrombocytopenia Syndrome

[Haematologica] The authors review interactions between adenoviral vectors and the hemostatic system that are of possible relevance in vaccine-associated thrombotic thrombocytopenia syndrome.

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape

[Journal of the American Chemical Society] Investigators developed a spherical cocktail neutralizing aptamer-gold nanoparticle to block the interaction between the receptor-binding domain of SARS-CoV-2 and host ACE2.

Todos Medical Announces All 31 Patients Enrolled to Date in Tollovir® Phase II Clinical Trial in Hospitalized COVID-19 Patients Have Completed Study Participation

[Todos Medical, Ltd.] Todos Medical, Ltd. together with its 3CL biology-focused joint venture partner NLC Pharma, announced that all 31 patients enrolled to date in Tollovir® Phase II clinical trial in hospitalized COVID-19 patients completed study participation.

Persistent Pulmonary Pathology after COVID-19 Is Associated with High Viral Load, Weak Antibody Response, and High Levels of Matrix Metalloproteinase-9

[Scientific Reports] The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19.

Oncotelic Initiates Phase II Trial Evaluating OT-101 in Combination with KEYTRUDA® for Mesothelioma

[Oncotelic Therapeutics, Inc.] Oncotelic Therapeutics, Inc. announced that it has submitted clinical study protocol to the US FDA for the initiation of a Phase II Trial for OT-101, the company’s TGF-β inhibitor, in combination with Anti-PD-1 as a treatment for patients with malignant pleural mesothelioma.

Lyophilized, Thermostable Spike or RBD Immunogenic Liposomes Induce Protective Immunity against SARS-CoV-2 in Mice

[Science Advances] The authors assessed low-dose immunization with lyophilized nanoparticles decorated with recombinant SARS-CoV-2 antigens.

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