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COVID-19

Japan Relaunches Its HPV Vaccination Drive. For Thousands of Women, It May Be Too Late

[ScienceInsider] On 1 April, Japan's health ministry will resume recommending that girls ages 12 to 16 get vaccinated against human papillomavirus (HPV)—“an important signal of confidence in the vaccine and its safety,” says Paul Bloem, HPV vaccine strategy lead at the World Health Organization.

Mice Infected with Mycobacterium tuberculosis Are Resistant to Acute Disease Caused by Secondary Infection with SARS-CoV-2

[PLoS Pathogens] In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.

CD4+ T Cell Dysfunction in Severe COVID-19 Disease is TNFα/TNFRI-Dependent

[American Journal of Respiratory and Critical Care Medicine] Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.

First Wave BioPharma Files US and PCT Patent Applications for Niclosamide in Long-Haul COVID-19

[First Wave BioPharma, Inc.] First Wave BioPharma, Inc. announced the continued enhancement of the intellectual property portfolio governing niclosamide as a treatment for COVID-19-related gastrointestinal infections.

Angiopathic Activity of LRG1 Is Induced by the IL-6/STAT3 Pathway

[Scientific Reports] Researchers examined the role of interleukin-6 (IL-6) in defective angiogenesis mediated by leucine-rich α-2-glycoprotein 1 (LRG1). IL-6 treatment induced LRG1 expression in endothelial cells and ex vivo angiogenesis cultures and promoted vascular growth with reduced mural cell coverage.

Key Benefits of Dexamethasone and Antibody Treatment in COVID-19 Hamster Models Revealed by Single Cell Transcriptomics

[Molecular Therapy] Pulmonary viral burden was reduced by anti-SARS-CoV-2 antibody treatment, and similar or increased by dexamethasone alone. Dexamethasone exhibited strong anti-inflammatory effects and prevented fulminant disease in a severe disease model.

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