COVID-19

[Signal Transduction and Targeted Therapy] Investigators identified that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α (HIF-1α) play key roles in the virus infection and pro-inflammatory responses.

[Science Translational Medicine] The authors investigated whether intranasally administered ChAdOx1 nCoV-19 reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G mutation in the spike protein.

[My Own Med, Inc. (BusinessWire, Inc.)] My Own Med, Inc. is playing an important role in support of the new NIH IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort) study.

[Science Advances] The authors summarize COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of January 1, 2021.

[npj Vaccines] The authors review the relevance of structural modifications of S in different vaccines and the different modes of antigen expression after vaccination with genetic adenovirus-vector and mRNA vaccines.

[Cell Discovery] Scientists developed recombinant human ACE2-Fc fusion protein (hACE2-Fc) and a hACE2-Fc mutant with reduced catalytic activity.