cyclin D1

[Biochemical Pharmacology] MICAL1 has been reported to be involved in the malignant processes of several types of cancer cells, however, the roles of MICAL1 in colorectal cancer (CRC) have not been well-characterized. Researchers investigated the cellular functions and molecular mechanisms of MICAL1 in CRCs.

[Molecular Cancer therapeutics] Investigators tested the activity of co-targeting of estrogen receptor, HER2, and cyclin-dependent kinases 4/6 therapy with tucatinib, palbociclib, and fulvestrant in HR+/HER2+ human breast tumor cell lines and xenograft models.

[Molecular Therapy-Nucleic Acids] Analysis of The Cancer Genome Atlas data and the authors' tumor models after ionizing radiation treatment indicated that increased expression of pre-mRNA processing factor 19 was positively correlated with DNA damage repair.

[Biochemistry and Cell Biology] Wistar-Kyoto rats and spontaneously hypertensive rats were used to detect the expression of Angptl2. Angiotensin II stimulated vascular smooth muscle cells to mimic hypertension in vitro.

[FEBS Journal] Investigators found that the RIIB subunit of protein kinase A is expressed specifically by β cells of mouse and human islets.

[Histopathology] In extrauterine low-grade endometrial stromal sarcoma (LG-ESS), the positive rate of JAZF1 gene rearrangement was significantly lower than in uterine LG-ESS, limiting the value of JAZF1 gene translocation for diagnosis.