Matinas BioPharma Awarded up to $3.75 Million from the Cystic Fibrosis Foundation to Support Development of Oral Amikacin (MAT2501) for the Treatment of NTM Infections in Cystic Fibrosis Patients

Matinas BioPharma Holdings, Inc. announced that it has been awarded up to $3.75 million from the Cystic Fibrosis Foundation.
[Matinas BioPharma Holdings, Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

Engineered Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fibrosis–Based Cell and Mice Models

Airway dehydration and impaired mucociliary clearance in cystic fibrosis is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogenic sodium absorption. Decreasing sodium absorption by inhibiting ENaC can reverse airway surface liquid dehydration. Researchers inhibited endogenous heterotrimeric ENaC channels by introducing inactivating mutant ENaC α mRNA.
[Science Advances]
Mukherjee, A., MacDonald, K. D., Kim, J., Henderson, M. I., Eygeris, Y., & Sahay, G. (2020). Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models. Science Advances, 6(47), eabc5911. https://doi.org/10.1126/sciadv.abc5911 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Calithera Biosciences Awarded Up To $2.4M from Cystic Fibrosis Foundation to Support Clinical Development of Arginase Inhibitor, CB-280

Calithera Biosciences, Inc. has been awarded up to $2.4M from the Cystic Fibrosis Foundation. The award will support clinical development of CB-280, Calithera’s investigational first-in-class arginase inhibitor, which promotes higher tissue levels of nitric oxide to reduce the risk of infections in people with cystic fibrosis.
[Calithera Biosciences, Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

Vertex Announces European Commission Approval for KALYDECO® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with Cystic Fibrosis as Early as Four Months of Age

Vertex Pharmaceuticals Incorporated announced that the European Commission has granted approval of the label extension for KALYDECO® granules to include the treatment of infants with cystic fibrosis.
[Vertex Pharmaceuticals Incorporated]
Press Release
Bookmark

No account yet? Register

0
Share

Identification of AAV Serotypes for Lung Gene Therapy in Human Embryonic Stem Cell-Derived Lung Organoids

Scientists screened the ability of multiple adeno-associated virus serotypes to transduce lung bud organoids, a model of human lung parenchyma generated from human embryonic stem cells.
[Stem Cell Research & Therapy]
Meyer-Berg, H., Zhou Yang, L., Pilar de Lucas, M., Zambrano, A., Hyde, S. C., & Gill, D. R. (2020). Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids. Stem Cell Research & Therapy, 11(1), 448. https://doi.org/10.1186/s13287-020-01950-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

The authors report the directed differentiation of human iPSCs into airway basal cells, a population resembling the stem cell of the airway epithelium.
[Cell Stem Cell]
Hawkins, F. J., Suzuki, S., Beermann, M. L., Barillà, C., Wang, R., Villacorta-Martin, C., Berical, A., Jean, J. C., Suer, J. L., Matte, T., Simone-Roach, C., Tang, Y., Schlaeger, T. M., Crane, A. M., Matthias, N., Huang, S. X. L., Randell, S. H., Wu, J., Spence, J. R., … Kotton, D. N. (2020). Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.09.017 Cite
Abstract
Bookmark

No account yet? Register

0
Share

The Odorant Receptor OR2W3 on Airway Smooth Muscle Evokes Bronchodilation via a Cooperative Chemosensory Tradeoff between TMEM16A and CFTR

Investigators characterized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excitation-contraction coupling in human ASM cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Full Article
Bookmark

No account yet? Register

0
Share

Mutant CFTR Drives TWIST1 Mediated Epithelial–Mesenchymal Transition

The authors investigated the occurrence of epithelial–mesenchymal transition (EMT) in airways native tissue, primary cells and cell lines expressing mutant cystic fibrosis transmembrane conductance regulator through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

FDA Approves KALYDECO® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with CF as Early as Four Months of Age

Vertex Pharmaceuticals Incorporated announced the FDA approved KALYDECO® for use in children with cystic fibrosis ages four months to less than six months old who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.
[Vertex Pharmaceuticals Incorporated]
Press Release
Bookmark

No account yet? Register

0
Share

Neutrophil Elastase Promotes Macrophage Cell Adhesion and Cytokine Production through the Integrin-Src Kinases Pathway

The authors demonstrated that monocyte-derived Mɸ exposed to neutrophil elastas releases active matrix metalloproteinases, increased expression of pro-inflammatory cytokines TNFα, IL-1β, and IL-8, and reduced capacity to phagocytose bacteria.
[Scientific Reports]
Krotova, K., Khodayari, N., Oshins, R., Aslanidi, G., & Brantly, M. L. (2020). Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. Scientific Reports, 10(1), 15874. https://doi.org/10.1038/s41598-020-72667-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells

The authors collected nasal cells by brushing to determine ionocyte abundance. Nasal and bronchial cells were also expanded in vitro and reprogrammed to differentiated epithelia for morphological and functional studies.
[Cells]
Full Article
Bookmark

No account yet? Register

0
Share
Share