cystic fibrosis

[Science Translational Medicine] In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.

[Immunology & Cell Biology] Researchers presented a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection.

[Hepatology Communications] Researchers generated iPSC-derived hepatocytes and iPSC-derived cholangiocytes cells and characterized them based on hepatocyte-specific and cholangiocyte-specific markers.

[PLoS Pathogens] Researchers showed that natural killer (NK) cells directly killed extracellular P. aeruginosa using NK effector molecules.

[European Respiratory Journal] Individual cystic fibrosis transmembrane conductance regulator function was defined by forskolin-induced swelling, measured as the relative size increase of intestinal organoids after stimulation with 0.8 µM forskolin, quantified as area under the curve.

[Scientific Reports] Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.