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dendritic cells

XIAP Restrains TNF-Driven Intestinal Inflammation and Dysbiosis by Promoting Innate Immune Responses of Paneth and Dendritic Cells

[Science Immunology] The authors used X-linked inhibitor of apoptosis protein (XIAP)-deficient mice to characterize the mechanisms underlying intestinal inflammation.

Type 1 Conventional Dendritic Cells: Ontogeny, Function, and Emerging Roles in Cancer Immunotherapy

[Trends in Immunology] The authors review the progress in defining the key developmental and functional attributes of type 1 conventional dendritic cells (cDC1s) and the approaches to optimizing the potency of cDC1s for anticancer immunity.

Specialized Transendothelial Dendritic Cells Mediate Thymic T Cell Selection against Blood-Borne Macromolecules

[Nature Communications] Investigators described an additional pathway of thymic self-antigens acquisition that enabled circulating antigenic macromolecules to access both murine and human thymi.

Optineurin Modulates the Maturation of Dendritic Cells to Regulate Autoimmunity through JAK2-STAT3 Signaling

[Nature Communications] Investigators showed that optineurin was upregulated in human and mouse dendritic cell (DC) maturation, and that deletion of Optn in mice via CD11c-Cre attenuated DC maturation and impaired the priming of CD4+ T cells, thus ameliorating autoimmune symptoms such as experimental autoimmune encephalomyelitis.

Lymphocyte Access to Lymphoma Is Impaired by High Endothelial Venule Regression

[Cell Reports] Scientists reported that lymphoma caused severe high endothelial venules (HEVs) regression in mouse models that phenocopied aggressive human B cell lymphomas, and that HEV dedifferentiation occurred as a consequence of a disrupted lymph-carrying conduit system.

The Impact of Hypoxia on Immune State in Cancer

[Life Sciences] Infiltration and activity of CD8+ T cells is reduced in hypoxic conditions, whereas regulatory T cells and myeloid-derived suppressor cells show high activities.

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