dendritic cells

[Nature] Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.

[Blood Advances] The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.

[Cell Reports] Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/− mice, which lacked macrophage influx following TBI and were resistant to brain damage.

[Mucosal Immunology] Lung dendritic cells (DCs) from tolerized mice induced a low Th2 response in vitro mirroring impact of tolerance in vivo. Wild type-Tol mice displayed a decrease in total, cDC1 and cDC2 subsets in the lung as compared to that in naive mice.

[Beneficial Microbes] The authors reported that the intestinal commensal microbe Limosilactobacillus reuteri ATCC PTA 6475 secretes 83.4 mM ethanol. Consistent with the activity of L. reuteri alcohol dehydrogenases, they found that L. reuteri tolerated various levels of ethanol.