dendritic cells

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

[Cellular & Molecular Immunology] Investigators discuss the migratory routes and immunological consequences of distinct dendritic cell (DC) subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.

[Nature Communications] Scientists reported that 3-hydroxy-L-kynurenamine was a biogenic amine produced via an alternative pathway of tryptophan metabolism.

[Oncogene] The authors summarize how T cell activation is controlled by dendritic cells and how the tumor microenvironment alters dendritic cell properties in the context of the anti-tumor immune cycle.

[Cellular & Molecular Immunology] Researchers described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers.

[Journal of Leukocyte Biology] miRNA profiles were evaluated and eight miRNAs were found to be differentially expressed in patient-derived cell lines in comparison to controls. miR-181c was predicted to target myeloid cell leukemia (MCL)1, which was confirmed by transfection assays, resulting in significantly reduced MCL1 mRNA and decreased live cell numbers.