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dendritic cells

Infection-Induced Lymphatic Zippering Restricts Fluid Transport and Viral Dissemination from Skin

[Journal of Experimental Medicine] Scientists demonstrated that cutaneous vaccinia virus infection by scarification activates dermal lymphatic capillary junction tightening and lymph node lymphangiogenesis, which were associated with reduced fluid transport and cutaneous viral sequestration.

Cell Death-Induced Immunogenicity Enhances Chemoimmunotherapeutic Response by Converting Immune-Excluded Into T Cell Inflamed Bladder Tumors

[Nature Communications] The authors hypothesized that TGF-β receptor inhibition may alter pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

Tim-3 Mediates T Cell Trogocytosis to Limit Antitumor Immunity

[Journal of Clinical Investigation] Scientists showed that human PD-1+Tim-3+ CD8+ tumor-infiltrating lymphocytes upregulated phosphatidylserine, a receptor for Tim-3, and acquire cell surface myeloid markers from antigen presenting cells through transfer of membrane fragments called trogocytosis.

Epigenetic Activation of Plasmacytoid DC Drives IFNAR-Dependent Therapeutic Differentiation of AML

[Cancer Discovery] In models of AML, leukemia cell differentiation and therapeutic benefit mediated by the histone deacetylases inhibitor panobinostat required activation of the type I interferon pathway.

Myd88 Knockdown with RNA Interference Induces In Vitro Immune Hyporesponsiveness in Dendritic Cells from Rhesus Monkeys

[Immunogenetics] The authors investigated the effect of Myd88 silencing on dendritic cell function and immune response. CD34+ cells were isolated from the bone marrow of rhesus monkeys by the immunomagnetic bead method and then infected with an adenovirus expressing Myd88-specific short hairpin RNA.

MYC Inhibition Reprograms Tumor Immune Microenvironment by Recruiting T Lymphocytes and Activating the CD40/CD40L System in Osteosarcoma

[Cell Death Discovery] Scientists found that the expression of the c-Myc oncogene was negatively correlated with T cell infiltration rate in osteosarcoma. Pharmacological inhibition of c-Myc with JQ-1 significantly reduced tumor burden and improved overall survival in an immunocompetent syngeneic murine model of osteosarcoma.

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