dendritic cells

[Molecular Therapy Oncolytics] The authors identified that FKBP4/NR3C1 axis was a novel negative regulator of TMEM173 in human breast cancer (BC) cells and demonstrated that FKBP4/NR3C1/TMEM173 signaling pathway could regulate autophagy and proliferation of BC cells as well as dendritic cell abundance through exosome release.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators characterized an unknown protein encoded by phospholipase A2 inhibitor and LY6/PLAUR domain-containing (PINLYP) gene that interacted with TBK1 and induced type I IFN in a TBK1- and IRF3-dependent manner.

[Cell Discovery] Researchers established an experimental system including a stimulus of interest, applied to an immune cell type in several contexts.

[Hypertension Research] Using multicolor flow cytometry, expression of maturation markers in total dendritic cells (DCs), myeloid DCs, and plasmacytoid DCs and the distribution of peripheral Th17-bearing and T-reg cells were defined.

[Nature Aging] The authors revealed an atlas of age-related changes in the abundance and phenotype of immune cell populations across 12 mouse tissues.

[Scientific Reports] Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.