Researchers developed mRNA-based JAK-STAT signaling pathway activity assays to quantitatively measure the cellular immune response on Affymetrix expression microarray data of various types of blood samples from virally infected patients, or vaccinated individuals, and to determine vaccine immunogenicity.
Emergex Vaccines Holding Limited announced that it has raised $11 million in a funding round supported by new and existing investors.The proceeds of this funding round will enable Emergex to further advance and execute its vaccine development strategy, producing vaccine candidates for some of the world’s most threatening and virulent diseases such as COVID-19, Dengue Fever and pandemic flu.
Scientists investigated how flaviviruses exploit Src family kinases for exit from infected cells. They identifyied Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles
Li, M. Y., Naik, T. S., Siu, L. Y. L., Acuto, O., Spooner, E., Wang, P., Yang, X., Lin, Y., Bruzzone, R., Ashour, J., Evans, M. J., & Sanyal, S. (2020). Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. Nature Communications, 11(1), 5189. https://doi.org/10.1038/s41467-020-19028-wCite
Scientists demonstrated that TLR2, together with its co-receptors CD14 and TLR6, was an innate sensor of Dengue virus particles inducing inflammatory cytokine expression and impairing vascular integrity in vitro.