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dengue

A Zika Virus Mutation Enhances Transmission Potential and Confers Escape from Protective Dengue Virus Immunity

[Cell Reports] To understand some of the pressures that influence Zika virus (ZIKV) evolution, scientists mimicked the natural transmission cycle by repeating serial passaging of ZIKV through cultured mosquito cells and either dengue virus (DENV)-naive or DENV-immune mice.

A Zika Virus Mutation Enhances Transmission Potential and Confers Escape from Protective Dengue Virus Immunity

[Cell Reports] To understand some of the pressures that influence Zika virus (ZIKV) evolution, scientists mimicked the natural transmission cycle by repeating serial passaging of ZIKV through cultured mosquito cells and either dengue virus (DENV)-naive or DENV-immune mice.

Flavivirus Replication Kinetics in Early-Term Placental Cell Lines with Different Differentiation Pathways

[Virology Journal] Researchers evaluated the replication kinetics of Zika virus and the related encephalitic flavivirus West Nile strain Kunjin virus in early-term placental cell lines.

Designed, Highly Expressing, Thermostable Dengue Virus 2 Envelope Protein Dimers Elicit Quaternary Epitope Antibodies

[Science Advances] Using molecular modeling, scientists found DENV2 E protein mutations that induced dimerization at low concentrations and enhanced production yield by more than 50-fold.

Immunotranscriptomic Profiling the Acute and Clearance Phases of a Human Challenge Dengue Virus Serotype 2 Infection Model

[Nature Communications] Researchers profiled the host immunotranscriptome response in humans before, during, and after infection with a partially attenuated rDEN2Δ30 challenge virus.

Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes

[Frontiers in Immunology] Scientists showed that hemocytes are recruited to the midgut of Aedes aegypti mosquitoes in response to the dengue and Zika viruses.

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