Measurement of Cellular Immune Response to Viral Infection and Vaccination

Researchers developed mRNA-based JAK-STAT signaling pathway activity assays to quantitatively measure the cellular immune response on Affymetrix expression microarray data of various types of blood samples from virally infected patients, or vaccinated individuals, and to determine vaccine immunogenicity.
[Frontiers in Immunology]
Bouwman, W., Verhaegh, W., Holtzer, L., & van de Stolpe, A. (2020). Measurement of Cellular Immune Response to Viral Infection and Vaccination. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.575074 Cite
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Emergex Vaccines Raises US$11 million to Advance Pipeline of Synthetic T-Cell Vaccines for Infectious Diseases

Emergex Vaccines Holding Limited announced that it has raised $11 million in a funding round supported by new and existing investors.The proceeds of this funding round will enable Emergex to further advance and execute its vaccine development strategy, producing vaccine candidates for some of the world’s most threatening and virulent diseases such as COVID-19, Dengue Fever and pandemic flu.
[Emergex Vaccines Holding Limited (Globe Newswire, Inc.)]
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Dengue Virus Infection Impedes Megakaryopoiesis in MEG-01 Cells where the Virus Envelope Protein Interacts with the Transcription Factor TAL-1

Investigators studied Dengue virus infection of MEG-01 cells to understand its effect on megakaryopoiesis and the generation of platelet-like-particles.
[Scientific Reports]
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Dengue Virus Susceptibility in Novel Immortalized Myeloid Cells

Investigators assessed the efficiency of dengue virus infection using the novel immortalized human myeloid cell lines iPS-ML and iPS-dendritic cell.
[Heliyon]
Yamanaka, A., Miyazaki, K., Shimizu, J., & Senju, S. (2020). Dengue virus susceptibility in novel immortalized myeloid cells. Heliyon, 6(11). https://doi.org/10.1016/j.heliyon.2020.e05407 Cite
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Lyn Kinase Regulates Egress of Flaviviruses in Autophagosome-Derived Organelles

Scientists investigated how flaviviruses exploit Src family kinases for exit from infected cells. They identifyied Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles
[Nature Communications]
Li, M. Y., Naik, T. S., Siu, L. Y. L., Acuto, O., Spooner, E., Wang, P., Yang, X., Lin, Y., Bruzzone, R., Ashour, J., Evans, M. J., & Sanyal, S. (2020). Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. Nature Communications, 11(1), 5189. https://doi.org/10.1038/s41467-020-19028-w Cite
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Sequential Immunization Induces Strong and Broad Immunity against All Four Dengue Virus Serotypes

Scientists tested whether sequential immunization induces stronger and broader immunity against four dengue virus serotypes than tetravalent-formulated immunization.
[NPJ Vaccines]
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TLR2 on Blood Monocytes Senses Dengue Virus Infection and Its Expression Correlates with Disease Pathogenesis

Scientists demonstrated that TLR2, together with its co-receptors CD14 and TLR6, was an innate sensor of Dengue virus particles inducing inflammatory cytokine expression and impairing vascular integrity in vitro.
[Nature Communications]
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