depression

[Translational Psychiatry] A post-stroke depression (PSD)-like model was established by treating neuronal cells with oxygen-glucose deprivation and corticosterone. Scientists found that protein pro-brain-derived neurotrophic factor (BDNF) levels were higher in the cortex and hippocampus in the PSD group than in the controls.

[COMPASS Pathways, Inc.] COMPASS Pathways, Inc. announced it will be conducting a Phase II clinical trial to assess the safety and tolerability of COMP360 psilocybin therapy in post-traumatic stress disorder.

[Cell Death & Disease] Scientists applied unpredictable stress stimuli to breast tumor-bearing mice and established a xenograft model of breast cancer that suffered mental stress. This was followed by behavioral tests, tumor growth tracking, immune analysis, miRNA screening, and tumor cell proliferation analysis.

[Journal of Pharmaceutical and Biomedical Analysis] Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis.

[Neural Regeneration Research] The authors provide an overview of microglia regulation of synaptic plasticity and learning and memory, and discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging, neurocognitive disorder, and mental disorders.

[Scientific Reports] Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.