dermal cells

[Nature] Scientist sequenced the DNA of cutaneous and acral melanomas from a large cohort of human patients and found a specific enrichment for BRAF mutations in cutaneous melanoma and enrichment for CRKL amplifications in acral melanoma.

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

[Journal of Nanobiotechnology] A nanocomposite-based hydrogel was constructed by loading methotrexate into ZnO/Ag to realize combined multiple target therapy of psoriasis.

[Pigment Cell & Melanoma Research] Researchers performed histology and immunohistochemistry analyses and demonstrated that a newly developed full-thickness 3D reconstructed human pigmented skin model and an epidermis-only model exhibit dispersed pigment throughout keratinocytes in the epidermis.

[Bioorganic Chemistry] Investigators evaluated the ability of pigment C-phycocyanin to bind to the main cellular targets related in the progression of melanoma through molecular docking, and the reflection of this bind in the biological effects in the B16F10 cell line through in vitro analysis.

[Experimental Cell Research] Researchers studied the outcomes of olfactomedin 4 downregulation in human immortalized keratinocytes – the HaCaT cells.