Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling

Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice]
Wang, Y., Liu, J., Zhang, Q., Wang, W., Liu, Q., Liu, S., Song, Y., Wang, X., Zhang, Y., Li, S., Yang, X., Lv, S., & Liu, G. (2021). Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling. Diabetes Research and Clinical Practice, 0(0). https://doi.org/10.1016/j.diabres.2021.108702 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Molecular Characterization of the Human Kidney Interstitium in Health and Disease

The diabetic interstitium was enriched for ECM organization and small-molecule catabolism. Cell type markers with unchanged expression (NOTCH3, EGFR, and HEG1) and those down-regulated in diabetic nephropathy (MYH11, LUM, and CCDC3) were identified.
[Science Advances]
Barwinska, D., El-Achkar, T. M., Ferreira, R. M., Syed, F., Cheng, Y.-H., Winfree, S., Ferkowicz, M. J., Hato, T., Collins, K. S., Dunn, K. W., Kelly, K. J., Sutton, T. A., Rovin, B. H., Parikh, S. V., Phillips, C. L., Dagher, P. C., Eadon, M. T., & Project, for the K. P. M. (2021). Molecular characterization of the human kidney interstitium in health and disease. Science Advances, 7(7), eabd3359. https://doi.org/10.1126/sciadv.abd3359 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Diabetic Condition Induces Hypertrophy and Vacuolization in Glomerular Parietal Epithelial Cells

A descriptive analysis of parietal epithelial cells was undertaken in diabetic db/db mice and in diabetic patients.
[Scientific Reports]
Kawaguchi, T., Hasegawa, K., Yasuda, I., Muraoka, H., Umino, H., Tokuyama, H., Hashiguchi, A., Wakino, S., & Itoh, H. (2021). Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells. Scientific Reports, 11(1), 1515. https://doi.org/10.1038/s41598-021-81027-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Current Trends on Applications of Stem Cells in Diabetic Nephropathy

Scientists review the potential mechanism of stem cells as new therapeutic agents in the treatment of diabetic nephropathy (DN). They also review recent findings and updated information about not only the utilization of stem cells on DN in both preclinical and clinical trials but limitations and future expectations of stem cell-based therapy for DN.
[Cell Death & Disease]
Liu, D., Zheng, W., Pan, S., & Liu, Z. (2020). Concise review: current trends on applications of stem cells in diabetic nephropathy. Cell Death & Disease, 11(11), 1–14. https://doi.org/10.1038/s41419-020-03206-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share