embryonic stem cells

[Cell Reports] Researchers characterized stage-specific methylation dynamics and the function of ten-eleven translocation (TET) during human cardiomyocyte differentiation.

[Nature Aging] Scientists showed accurate tracking of the aging process in hepatocytes, demonstrated attenuated epigenetic aging in muscle stem cells and tracked age dynamics in embryonic stem cells.

[Cell Reports] Researchers characterized stage-specific methylation dynamics and the function of Ten-eleven translocations (TETs) during human cardiomyocyte differentiation. Human ESCs in which all three TET genes were inactivated failed to generate cardiomyocytes, with altered mesoderm patterning and defective cardiac progenitor specification.

[Biomaterials] Scientists address the role of matrix mellanoproteinases (MMPs) in stem cell differentiation by assaying MMP expression and activity during differentiation of mouse ESCs on mouse embryonic fibroblast derived matrices of varying stiffness and composition.

[Molecular Cell] Researchers showed that linker histone H1 was post-translationally modulated by SUMO2/3, which facilitated its fixation onto ultra-condensed heterochromatin in ESCs.

[Science] Scientists offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote gastrulation, and discuss the implications of ESC–based models of early mammalian embryogenesis on the function of this iconic structure.