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embryonic stem cells

The IVF-Generated Human Embryonic Microenvironment Reverses Progestin Resistance in Endometrial Cancer Cells by Inducing Cancer Stem Cell Differentiation

[Cancer Letters] Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.

Defective Chromatin Architectures in Embryonic Stem Cells Derived from Somatic Cell Nuclear Transfer Impair Their Differentiation Potentials

[Cell Death & Disease] Researchers employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and 3D genome organization of nuclear transfer ESCs (ntESCs) and showed that the chromatin accessibility and genome structures of somatic cells were re-arranged to ESC-like states overall in ntESCs.

Neuronal and Cardiac Toxicity of Pharmacological Compounds Identified through Transcriptomic Analysis of Human Pluripotent Stem Cell-Derived Embryoid Bodies

[Toxicology and Applied Pharmacology] Scientists used human iPSC-derived embryoid bodies as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds.

Mechanical Regulation of Early Vertebrate Embryogenesis

[Nature Reviews Molecular Cell Biology] The authors review insights into mechanical control of early vertebrate development, including the role of forces in tissue patterning and embryonic axis formation.

Cell-Cell Communication through FGF4 Generates and Maintains Robust Proportions of Differentiated Cell Types in Embryonic Stem Cells

[Development] Researchers reported that the differentiation of robust proportions of epiblast-like and primitive endoderm-like cells in mouse ESC cultures emerged at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal.

Inherent Genomic Properties Underlie the Epigenomic Heterogeneity of Human Induced Pluripotent Stem Cells

[Cell Reports] Scientists showed that seven human iPSC lines with variable germline potential exhibited substantial epigenomic heterogeneity, despite their uniform transcriptomes.

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