embryonic stem cells

[Nature] Researchers identified a non-canonical tricarboxylic acid (TCA) cycle that was required for changes in cell state. During exit from pluripotency, ESCs switched from canonical to non-canonical TCA-cycle metabolism.

[Journal of Cellular and Molecular Medicine] Investigators found that the limited expansion of ESC CD34+ cell-derived erythroid cells was associated with defective cell cycle of erythroid progenitors.

[Journal of Molecular Cell Biology] Scientists mimicked histone H3 at the 56th lysine (H3K56) mutant incorporation in mESCs by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.

[Genome Biology] Through high-resolution 3D-structured illumination microscopy and functional analysis, researchers reported multiple biological processes associated with the meiosis-specific cohesin components, α-kleisin REC8 and STAG3, and the distinct loss of function of meiotic cohesin during the cell cycle of ESCs.

[Science Advances] Researchers demonstrated of the use of extracellular vesicles derived from ESCs undergoing cardiac differentiation as biomimetic tools to induce cardiac reprogramming with extremely high efficiency, establishing a general, more readily accessible platform for generating a variety of specialized somatic cells through direct lineage conversion.

[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.