embryonic stem cells

[Neural Regeneration Research] Scientists provide a systematic overview of the progress and remaining challenges for the generation of non-human primate iPSCs/ESCs for the preclinical testing and validation of cell replacement therapies.

[Stem Cell Reports] By leveraging recent knowledge of the signaling pathways involved in liver development, investigators described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.

[Nature Communications] The authors indicated that canonical Wnt signaling was required in a precise and regulated manner for normal choroid plexus development in the mammalian brain.

[Nature Communications] Researchers characterized the expression pattern and examined the function of Lima1 in mouse embryos and PSC lines.

[Nature] Scientists showed that the BRG1/BRM-associated factor chromatin-remodeling complex ATPase gene Brm safeguarded cell identity during directed cardiogenesis of mouse ESCs.

[Molecular Reproduction and Development] Scientists introduce the research advance of both somatic cell reprogramming and early embryonic development, indicating that the mechanisms of iPSCs also shares common features with that of early embryonic development in several aspects.