Endothelial Cell News

[British Journal of Cancer] Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages.

[Cancer Research] Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.

[Proceedings of the National Academy of Sciences of the United States of America] Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.

[Scientific Reports] Endothelial dysfunction was determined by flow-mediated dilatationd asymmetric dimethylarginine (ADMA) levels. Serum ADMA, high sensitive C-reactive protein, serum PTX3, malondialdehyde, Cu/Zn-superoxide dismutase, glutathione peroxidase levels and FMD were studied in baseline and after 12 weeks of Morinda citrifolia, omega-3 and extract with Alaskan blueberry.

[Scientific Reports] Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.

[East Carolina University] Dr. Paul Cook, chief of the Division of Infectious Diseases at East Carolina Univesity’s Brody School of Medicine, began enrolling patients June 1 in a clinical trial investigating a new treatment aimed at preventing and shortening the duration of Acute Respiratory Distress Syndrome (ARDS). ARDS is a characteristic of COVID-19 that occurs when fluid builds up in the lungs and prevents oxygen from entering the bloodstream.