New Tools to Prevent Cancer Growth and Spread: A ‘Clever’ Approach

Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages.
[British Journal of Cancer]
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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
[Cancer Research]
Zhang, Y., Cedervall, J., Hamidi, A., Herre, M., Viitaniemi, K., D’Amico, G., … Olsson, A.-K. (2020). Platelet-specific PDGFB ablation impairs tumor vessel integrity and promotes metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-3533 Cite
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ECU, Vidant Begin Trial of COVID-19 Treatment

Dr. Paul Cook, chief of the Division of Infectious Diseases at East Carolina Univesity’s Brody School of Medicine, began enrolling patients June 1 in a clinical trial investigating a new treatment aimed at preventing and shortening the duration of Acute Respiratory Distress Syndrome (ARDS). ARDS is a characteristic of COVID-19 that occurs when fluid builds up in the lungs and prevents oxygen from entering the bloodstream.
[East Carolina University]
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Myeloid ALX/FPR2 Regulates Vascularization Following Tissue Injury

Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.
[Proceedings of the National Academy of Sciences of the United States of America]
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The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study

Endothelial dysfunction was determined by flow-mediated dilatationd asymmetric dimethylarginine (ADMA) levels. Serum ADMA, high sensitive C-reactive protein, serum PTX3, malondialdehyde, Cu/Zn-superoxide dismutase, glutathione peroxidase levels and FMD were studied in baseline and after 12 weeks of Morinda citrifolia, omega-3 and extract with Alaskan blueberry.
[Scientific Reports]
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Essential Contribution of Macrophage Tie2 Signaling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.
[Scientific Reports]
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