endothelial cells

[Communications Biology] Researchers explored the metabolic reprogramming relevant to lung adenocarcinoma metastasis and decoded the underlying intercellular alterations.

[Cancer Science] Scientists investigated how tumor epithelial cells influenced tumor growth and immune responses of hepatocellular carcinoma focusing on CD8+ T-cell infiltration and exhaustion.

[Scientific Reports] Researchers reported soluble Robo4 was the product of constitutive ectodomain shedding of endothelial cell surface Robo4 by disintegrin metalloproteinases ADAM10 and ADAM17 and acted to inhibit angiogenic Slit3 signaling.

[Nature Cardiovascular Research] The authors identified cell-specific transcriptional signatures associated with age and heart failure and reveal the emergence of disease-associated cell states. Notably, cardiomyocytes converged toward common disease-associated cell states, whereas fibroblasts and myeloid cells underwent dramatic diversification.

[Nature Reviews Immunology] Scientists discuss emerging evidence suggesting a tissue-specific and vessel type-specific immunomodulatory role for distinct subtypes of endothelial cells, collectively referred to as ‘immunomodulatory ECs’.

[Journal of Physiological Sciences] Researchers investigated whether aortic stiffness was also modulated by a shorter duration of autophagy deficiency.