Targeting Epigenetically Maladapted Vascular Niche Alleviates Liver Fibrosis in Nonalcoholic Steatohepatitis

Investigators used multiomics analysis of human cirrhotic liver, a Western diet – and carbon tetrachloride – induced minipig nonalcoholic steatohepatitis model, and genetically modified mice to unravel the landscape of the vascular adaptome at the single-cell level, in which endothelial cells and TH17 cells jointly contributed to liver cirrhosis.
[Science Translational Medicine]
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Functional Characterization of a Bioengineered Liver after Heterotopic Implantation in Pigs

Researchers reported a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold previously reendothelialized with human umbilical vein endothelial cells.
[Communications Biology]
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Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity

HUVECs were exposed to either laminar flow or oscillating disturbed flow for 24 hours in a cone-and-plate device.
[Circulation Research]
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Brain Microvasculature Endothelial Cell Orientation on Micropatterned Hydrogels Is Affected by Glucose Level Variations

Scientists reported on an effort to decipher the alignment of brain microvasculature endothelial cells to physical constrains generated via adhesion control on hydrogel surfaces and explored the corresponding responses upon glucose level variations emulating the hypo- and hyperglycaemic effects in diabetes.
[Scientific Reports]
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Comparative Study of the Effects of Cigarette Smoke versus Next Generation Tobacco and Nicotine Product Extracts on Endothelial Function

The authors analyzed key parameters of endothelial function after exposure to aqueous smoke extracts of a heated tobacco product, an electronic cigarette, a conventional cigarette and pure nicotine.
[Redox Biology]
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Long Noncoding RNA p21 Enhances Autophagy to Alleviate Endothelial Progenitor Cells Damage and Promote Endothelial Repair in Hypertension through SESN2/AMPK/TSC2 Pathway

The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.
[Pharmacological Research]
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Involvement of Multiple Scavenger Receptors in Advanced Glycation End Product-Induced Vessel Tube Formation in Endothelial Cells

Researchers examined the involvement of advanced glycation end (AGE)-related receptors on AGE-induced angiogenesis in endothelial cells.
[Experimental Cell Research]
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The Effect of Dihydroceramide Desaturase 1 Inhibition on Endothelial Impairment Induced by Indoxyl Sulfate

Investigators assessed the therapeutic potential of dihydroceramide desaturase 1 inhibition, the last enzyme involved in de novo ceramide synthesis, to mitigate the vascular effects of the protein-bound uremic toxins indoxyl sulfate
[Vascular Pharmacology]
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CUL5-Mediated Visfatin (NAMPT) Degradation Blocks Endothelial Proliferation and Angiogenesis via the MAPK/PI3K-AKT Signaling

Researchers found that NAMPT overexpression protected human coronary artery endothelial cells from H2O2-induced injury through promoting cell viability, inhibiting cell apoptosis, enhancing cell motility, and promoting tube formation.
[Journal of Cardiovascular Pharmacology]
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Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization

The authors investigated the effect of crosstalk between retinal pigment epithelial (RPE) cells and choroidal endothelial cells via the ANXA1/FPR2/NLRP3 inflammasome/pyroptosis axis on the development of choroidal neovascularization in vitro and in vivo.
[Inflammation]
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Bovine Milk Exosomes Alleviate Cardiac Fibrosis via Enhancing Angiogenesis In Vivo and In Vitro

The proangiogenic effect of bovine milk exosomes was analyzed both in isoproterenol-induced cardiac fibrosis rats in vivo and in HUVECs after oxygen and glucose deprivation in vitro.
[Journal of Cardiovascular Translational Research]
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