Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

CXCR1 and CXCR2 were not detected on several clones of cord blood- endothelial colony-forming cell using different antibodies available, in contrast to well-known positive cells.
[Stem Cell Reviews and Reports]
Blandinières, A., Hong, X., Philippe, A., Bièche, I., Vacher, S., Rossi, E., Detriche, G., Gendron, N., Gaussem, P., Guerin, C. L., Melero-Martin, J. M., & Smadja, D. M. (2020). Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10081-y Cite
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Role of Fibrocytes and Endothelial ProgenitoPr Cells among Low-Differentiated CD34+ Cells in the Progression of Lung Sarcoidosis

Scientists characterized of the CD34+ cell population in peripheral blood in patients with sarcoidosis (SA) with reference to the control group. Moreover in patients with SA, fibrocytes and endothelial cells were analyzed and their relationship to the fibrosis process based on assessment of diffusing capacity for carbon monoxide.
[BMC Pulmonary Medicine]
Elżbieta, R., Iwona, K., Joanna, B., Karina, J.-R., & Piotr, R. (2020). Role of fibrocytes and endothelial progenitor cells among low-differentiated CD34+ cells in the progression of lung sarcoidosis. BMC Pulmonary Medicine, 20(1), 306. https://doi.org/10.1186/s12890-020-01345-x Cite
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Paracrine Effect of Human Adipose-Derived Stem Cells on Lymphatic Endothelial Cells

Investigators evaluated, in vitro, the potential paracrine effect of human adipose-derived stem cells to promote lymphangiogenesis in lymphatic endothelial cells isolated from rat diaphragmatic lymphatic vessels.
[Regenerative Medicine]
Marcozzi, C., Frattini, A., Borgese, M., Rossi, F., Barone, L., Solari, E., Valli, R., & Gornati, R. (2020). Paracrine effect of human adipose-derived stem cells on lymphatic endothelial cells. Regenerative Medicine. https://doi.org/10.2217/rme-2020-0071 Cite
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Cardiovascular Tissue Regeneration System Based on Multiscale Scaffolds Comprising Double-Layered Hydrogels and Fibers

Mulltiscale scaffolds compartmentalized cells into the core region of cardiac tissue and the peripheral region of blood vessels to construct cardiovascular tissue, which was accomplished by a triple culture system of adipose-derived mesenchymal stem cells with C2C12 myoblasts on polycaprolactone fibers along with human umbilical vein endothelial cells (HUVECs) in fibrin hydrogel.
[Scientific Reports]
Kook, Y.-M., Hwang, S., Kim, H., Rhee, K.-J., Lee, K., & Koh, W.-G. (2020). Cardiovascular tissue regeneration system based on multiscale scaffolds comprising double-layered hydrogels and fibers. Scientific Reports, 10(1), 20321. https://doi.org/10.1038/s41598-020-77187-8 Cite
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Decreased Blood Vessel Density and Endothelial Cell Subset Dynamics during Aging of the Endocrine System

Angiogenesis and β‐cell expansion in the pancreas were coupled by a distinct age‐dependent subset of endothelial cells (ECs). While this EC subpopulation supported pancreatic β cells, it declined during aging concomitant with increased expression of the gap junction protein Gja1.
[EMBO Journal]
Chen, J., Lippo, L., Labella, R., Tan, S. L., Marsden, B. D., Dustin, M. L., Ramasamy, S. K., & Kusumbe, A. P. (2020). Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system. The EMBO Journal, n/a(n/a), e105242. https://doi.org/10.15252/embj.2020105242 Cite
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RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

Researchers examined expression of RIPK1 protein and mRNA in both human and mouse atherosclerotic lesions, and using loss-of-function approaches in vitro in macrophages and endothelial cells to measure inflammatory responses. They administered weekly injections of RIPK1 anti-sense oligonucleotides to Apoe-/- mice fed a cholesterol-rich diet for eight weeks.
[Circulation]
Karunakaran Denuja, Nguyen My-Anh, Geoffrion Michele, Vreeken Dianne, Lister Zachary, Cheng Henry S., Otte Nicola, Essebier Patricia, Wyatt Hailey, Kandiah Joshua W., Jung Richard, Alenghat Francis J., Mompeon Ana, Lee Richard, Pan Calvin, Gordon Emma, Rasheed Adil, Lusis Aldons J., Liu Peter, … Rayner Katey J. (n.d.). RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.118.038379 Cite
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Insulin-Like Growth Factor-I Predicts Sinusoidal Obstruction Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation

Investigators prospectively measured insulin-like growth factor-l (IGF-l) concentrations in 121 pediatric patients before, during, and after allogeneic hematopoietic stem cell transplantatio. Overall, IGF-l levels were significantly reduced compared with healthy sex- and age-matched children.
[Bone Marrow Transplantation]
Ebbesen, M., Weischendorff, S., Kielsen, K., Kammersgaard, M., Juul, A., & Müller, K. G. (2020). Insulin-like growth factor-I predicts sinusoidal obstruction syndrome following pediatric hematopoietic stem cell transplantation. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01127-3 Cite
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Blood-Derived Extracellular Vesicles Isolated from Healthy Donors Exposed to Air Pollution Modulate In Vitro Endothelial Cells Behavior

Researchers investigated the ability to activate endothelial primary cells by plasmatic extracellular vesicles (EVs) after both high and low particular matter (PM) exposure. Normal weight-high-PM EVs showed an increased endothelial activation, measured as CD105+/CD62e+ EVs ratio.
[Scientific Reports]
Rota, F., Ferrari, L., Hoxha, M., Favero, C., Antonioli, R., Pergoli, L., Greco, M. F., Mariani, J., Lazzari, L., & Bollati, V. (2020). Blood-derived extracellular vesicles isolated from healthy donors exposed to air pollution modulate in vitro endothelial cells behavior. Scientific Reports, 10(1), 20138. https://doi.org/10.1038/s41598-020-77097-9 Cite
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In Vitro Modeling of Solid Tumor Interactions with Perfused Blood Vessels

Researchers introduced a microfluidic model of the solid tumor-vascular interface composed of a human umbilical vein endothelial cell (HUVEC)-lined, perfusable, bioengineered blood vessel and tumor spheroids embedded in an extracellular matrix.
[Scientific Reports]
Kwak, T. J., & Lee, E. (2020). In vitro modeling of solid tumor interactions with perfused blood vessels. Scientific Reports, 10(1), 20142. https://doi.org/10.1038/s41598-020-77180-1 Cite
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Macrophage Expression and Prognostic Significance of the Long Pentraxin PTX3 in COVID-19

RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells expressed high levels of PTX3 in patients with COVID-19.
[Nature Immunology]
Brunetta, E., Folci, M., Bottazzi, B., De Santis, M., Gritti, G., Protti, A., Mapelli, S. N., Bonovas, S., Piovani, D., Leone, R., My, I., Zanon, V., Spata, G., Bacci, M., Supino, D., Carnevale, S., Sironi, M., Davoudian, S., Peano, C., … Mantovani, A. (2020). Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19. Nature Immunology, 1–6. https://doi.org/10.1038/s41590-020-00832-x Cite
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Cancer-Initiating Cells in Human Pancreatic Cancer Organoids Are Maintained by Interactions with Endothelial Cells

Organoid-derived CD44(−) cancer cells were capable of organoid re-formation and could be re-programed as CD44-expressing cancer-initiating cells in the organoid culture system.
[Cancer Letters]
Choi, J.-I., Jang, S. I., Hong, J., Kim, C. H., Kwon, S. S., Park, J. S., & Lim, J.-B. (2020). Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.10.012 Cite
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