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endothelial cells

Therapeutic Potential of Colchicine in Cardiovascular Medicine: A Pharmacological Review

[Acta Pharmacologica Sinica] The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.

Development of a 3D Atlas of the Embryonic Pancreas for Topological and Quantitative Analysis of Heterologous Cell Interactions

[Development] Scientists presented a light-sheet fluorescence microscopy approach to image the pancreas in 3D and map tissue interactions at key time points in the mouse embryo.

Understanding Nanomaterial-Liver Interactions to Facilitate the Development of Safer Nanoapplications

[Advanced Materials] The authors systemically review the diverse interactions of nanomaterials with the liver, specifically on major liver cell types including Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and hepatocytes as well as the detailed molecular mechanisms involved.

CCN2-Induced Lymphangiogenesis Is Mediated by the Integrin αvβ5–ERK Pathway and Regulated by DUSP6

[Scientific Reports] The authors found that communication network factor 2 (CCN2) induced phosphorylation of ERK in primary cultured lymphatic endothelial cells, which was almost completely inhibited by the blockade of integrin αvβ5 and partially decreased by the blockade of integrin αvβ3.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

[Journal of Investigative Dermatology] Scientists showed that androgen receptor-mediated paracrine signaling, mainly TGF-β signaling, from dermal papilla (DP) cells induced apoptosis of microvascular endothelial cells in the DP of balding scalp of androgenetic alopecia.

Thymosin Beta-4 Improves Endothelial Function and Reparative Potency of Diabetic Endothelial Cells Differentiated from Patient Induced Pluripotent Stem Cells

[Stem Cell Research & Therapy] Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.

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