Effects of Photobiomodulation on Annulus Fibrosus Cells Derived from Degenerative Disc Disease Patients Exposed to Microvascular Endothelial Cells Conditioned Medium

Researchers examined the effects of photobiomodulation (PBM), administered at various wavelengths and doses, on endothelial cell (EC)-stimulated human annulus fibrosus cells. Results showed that PBM selectively inhibited the EC-mediated production of inflammatory mediators, catabolic enzymes, and neurotrophins by human annulus fibrosus cells in a dose- and wavelength-dependent manner.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Snail Promotes the Generation of Vascular Endothelium by Breast Cancer Cells

Investigators reported a new and unexpected function of Snail in endothelium generation by breast cancer cells. They showed that high Snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Prediction of Post-Treatment Retinal Sensitivity by Baseline Retinal Perfusion Density Measurements in Eyes with Branch Retinal Vein Occlusion

Retinal sensitivity was measured using microperimetry and perfusion density was measured by optical coherence tomography angiography. Researchers also investigated the possibility that the PD, one month after anti-VEGF treatment, was a predictor of retinal sensitivity after one year of successful macular oedema management with anti-VEGF.
[Scientific Reports]
Bookmark

No account yet? Register

0
Share

Nanotechnology for Angiogenesis: Opportunities and Challenges

The authors summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail.
[Chemical Society Reviews]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human iPSCs in an organ-like environment, investigators generated functional engineered human mini-livers and performed transplantation in a rat model.
[Cell Reports]
Takeishi, K., l’Hortet, A. C. de, Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R. M., Yuan, F., Fukumitsu, K., Tobita, K., Sun, W., Franks, J., Delgado, E. R., Shapiro, E. M., Fraunhoffer, N. A., Duncan, A. W., … Soto-Gutierrez, A. (2020). Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells. Cell Reports, 31(9). https://doi.org/10.1016/j.celrep.2020.107711 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Scientists showed that tri-cellular combinations of human induced pluripotent stem cells (iPSC)-derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells enhanced maturation in easily constructed, scaffold-free, three-dimensional microtissues.
[Cell Stem Cell]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Blocking Endothelial Apoptosis Revascularises the Retina in a Model of Ischemic Retinopathy

Researchers investigated the role of endothelial cell (EC) apoptosis in retinal hypoxia using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis caused capillary regression and retinal ischemia followed by neovascularisation.
[Journal of Clinical investigation]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Molecular Mechanisms of Methylglyoxal-Induced Aortic Endothelial Dysfunction in Human Vascular Endothelial Cells

Investigators found that methylglyoxal significantly induced autophagy, declined the pro-angiogenic effect, decreased proliferation, migration, and formation of tube-like structures, and increased autophagic vacuoles, flux and autophagosomes in the HAoEC in a dose-dependent manner.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin

The authors demonstrated that neuropilin (NRP)2 promoted Rac-1 mediated endothelial cell adhesion and migration over fibronectin matrices in a mechanistically distinct fashion to NRP1, showing no dependence on β3 integrin expression, or VEGF stimulation
[Frontiers in Cell and Developmental Biology]
Full Article
Bookmark

No account yet? Register

0
Share

Angiogenic Cytokines Can Reflect the Synovitis Severity and Treatment Response to Biologics in Rheumatoid Arthritis

To determine the clinical significance of angiogenic cytokines in rheumatoid arthritis (RA), the levels of pro-angiogenic cytokines, including VEGF, placenta growth factor, and IL-6, were measured in the synovial fluid and sera of RA patients using ELISA.
[Experimental and Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

Amplification of Transglutaminase 2 Enhances Tumor-Promoting Inflammation in Gastric Cancers

Scientists investigated a novel role for transglutaminase 2 (TGM2) in the development of tumor-promoting inflammation and recruitment of tumor-associated macrophages to gastric cancer (GC) tissues. When estimated by array comparative genomic hybridization and droplet digital PCR, the copy numbers of the TGM2 gene were amplified in 13.6% of GC patients and positively associated with TGM2 expression.
[Experimental and Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share
Share