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endothelial cells

Mitigating the Non-Specific Uptake of Immunomagnetic Microparticles Enables the Extraction of Endothelium from Human Fat

[Communications Biology] The authors investigated the challenges underlying the overgrowth of human adipose tissue-derived microvascular endothelial cells by stromal cells to facilitate the development of a reliable method for their acquisition.

Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

[Gastroenterology] Scientists proposed that IL-13 decreased TSPAN12, likely contributing to the chronicity of eosinophilic esophagitis by promoting tissue remodeling through fibroblast-endothelial cell crosstalk.

Inhibition of Mevalonate Metabolism by Statins Augments the Immunoregulatory Phenotype of Vascular Endothelial Cells and Inhibits the Costimulation of CD4+ T Cells

[American Journal of Transplantation] Researchers performed full transcriptomic RNA sequencing and qPCR to evaluate the effects of mevalonate on the immunoregulatory phenotype of endothelial cells.

Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation

[Science] In a model of genetically driven closure of choroid plexus endothelial cells, the authors observed a deficit in short-term memory and anxiety-like behavior, suggesting that choroid plexus closure may have correlated with mental deficits.

Antiangiogenic Antibody BD0801 Combined with Immune Checkpoint Inhibitors Achieves Synergistic Antitumor Activity and Affects the Tumor Microenvironment

[BMC Cancer] The anti-cancer activities of BD0801 and its potential synergistic anti-tumor effects when combined with different immunotherapies were assessed by using in vitro assays and in vivo tumor models.

Renal Microvascular Endothelial Cell Responses in Sepsis-Induced Acute Kidney Injury

[Nature Reviews Nephrology] Comprehensive studies are needed to investigate the relationships between segment-specific changes in the microvasculature and kidney function loss in sepsis-AKI.

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