Euscaphic Acid and Tormentic Acid Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via PI3K/AKT or ERK 1/2 Signaling Pathway

Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways.
[Life Sciences]
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Sirtuins Family as a Target in Endothelial Cell Dysfunction: Implications for Vascular Aging

The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction.
[Biogerontology ]
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LncRNA SNHG1 Regulates Vascular Endothelial Cell Proliferation and Angiogenesis via miR-196a

The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis.
[Journal of Molecular Histology]
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S-Phase Kinase-Associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis In Vivo

Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy.
[Scientific Reports]
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Vascular Permeability in Retinopathy Is Regulated by VEGFR2 Y949 Signaling to VE-Cadherin

By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding.
[eLife]
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miR-548aq-3p Is a Novel Target of Far Infrared Radiation Which Predicts Coronary Artery Disease Endothelial Colony Forming Cell Responsiveness

Gene Ontology (GO) analysis of far infrared radiation (FIR) up-regulated genes indicated that the pathways enriched in FIR-responsive endothelial colony forming cells were involved in cell viability, angiogenesis and transcription.
[Scientific Reports]
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Notch Signaling Drives Synovial Fibroblast Identity and Arthritis Pathology

Scientists identified a critical role for NOTCH3 signaling in the differentiation of perivascular and sublining fibroblasts that expressed CD90. Using single-cell RNA sequencing and synovial tissue organoids, they found that NOTCH3 signaling drove both transcriptional and spatial gradients—emanating from vascular endothelial cells outwards—in fibroblasts.
[Nature Communications]
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A Necroptotic-Independent Function of MLKL in Regulating Endothelial Cell Adhesion Molecule Expression

Investigators demonstrated that mixed-lineage kinase domain-like protein (MLKL) promoted vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells.
[Cell Death & Disease]
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LncRNA OIP5-AS1 Promotes Cell Proliferation and Migration and Induces Angiogenesis via Regulating miR-3163/VEGFA in Hepatocellular Carcinoma

Scientists explored the inherent mechanism of lncRNA OIP5-AS1 -AS1 in hepatocellular carcinoma (HCC). In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues.
[Cancer Biology & Therapy]
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