endothelial cells

[Scientific Reports] Researchers demonstrated that the administration of cyclophilin A, a ligand of basigin which was expressed in barrier-forming endothelial cells, realized the artificial opening of blood–brain barrier.

[Nature] Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.

[Bone Marrow Transplantation] Further preclinical and clinical studies will explore defibrotide’s potential utility in a broader range of disorders resulting from endothelial cell activation and dysfunction.

[Leukemia] Spred1 knockout, regardless if occurred in HSCs or in endothelial cells, increased miR-126 in Lin−Sca-1+c-Kit+, a population enriched in leukemic stem cells (LSCs), resulting in expansion of LSCs, likely through hyperactivation of the MAPK/ERK pathway that augmented Bcl-2 expression and stability.

[Journal of Anatomy] The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponded to embryonic day 14.5 to embyronic day 16.5 in the hard palate.

[Tissue Engineering and Regenerative Medicine] MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.