endothelial cells

[Development] Using mouse ESCs (mESCs) to recapitulate murine embryonic development, the authors studied the requirement for Notch signaling during the earliest B-lymphopoiesis and found that Rbpj-deficient mESCs were able to generate B-1 cells.

[Scientific Reports] Investigators used isolated murine mesentery arterioles and co-cultures of human coronary artery endothelial cells and smooth muscle cells to test the hypothesis that heme oxygenase 1 mediated the effects of fluid shear stress on placental growth factor.

[Science Translational Medicine] Researchers found that erythropoietin (EPO) promoted the formation of abdominal aortic aneurysm (AAA) in both Apoe−/− and wild type mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of smooth muscle cells and that EPO/EPO receptor signaling was essential for angiotensin II-induced AAA.

[Scientific Reports] Single-cell RNA sequencing technology was used to decipher the cellular heterogeneity among pulmonary arterial endothelial cells in the human pulmonary arteries isolated from explanted lungs from three patients with pulmonary arterial hypertension undergoing lung transplantation and three healthy donor lungs not utilized for transplantation.

[Cell Death Discovery] Scientists investigated the heterogeneity of vascular cell populations under disturbed blood flow (d-flow). A d-flow-induced Spp1hi vascular smooth muscle cell subpopulation appeared to be endowed with osteoblast differentiation, suggesting a role in arterial stiffness.

[Hypertension] Scientists evaluated the effect of G-protein–coupled receptor 35 on endothelial cell functions and hemodynamic homeostasis.