HE4 was found to activate STAT3 signaling and promote upregulation of the pro-angiogenic STAT3 target genes IL8 and HIF1A in immune cells, ovarian cancer cells, and endothelial cells. Moreover, HE4 promoted increased in tube formation in an in vitro model of angiogenesis, which was also dependent upon STAT3 signaling.
The authors review the role of hypoxia and reactive oxygen species as the main stimulating factors of tissue damage due to vascular damage and endothelial-to-mesenchymal transition (EndMT). They consider drugs that may be clinically useful for regulating EndMT in various diseases.
[Experimental and Molecular Medicine]
Scientists summarize the dynamic changes in extracellular matrix (ECM) components and their modification and degradation during hypertension and after antihypertensive treatment. They also discuss how alterations in the ECM amount, assembly, mechanical properties, and degradation fragment generation provide input into the pathological process of hypertension.
[Antioxidants & Redox Signaling]
Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways.
The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction.
The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis.
[Journal of Molecular Histology]
The authors demonstrated endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19.
Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy.
By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding.
Gene Ontology (GO) analysis of far infrared radiation (FIR) up-regulated genes indicated that the pathways enriched in FIR-responsive endothelial colony forming cells were involved in cell viability, angiogenesis and transcription.
Scientists identified a critical role for NOTCH3 signaling in the differentiation of perivascular and sublining fibroblasts that expressed CD90. Using single-cell RNA sequencing and synovial tissue organoids, they found that NOTCH3 signaling drove both transcriptional and spatial gradients—emanating from vascular endothelial cells outwards—in fibroblasts.