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endothelial cells

Inverse and Reciprocal Regulation of p53/p21 and BMI-1 Modulates Vasculogenic Differentiation of Dental Pulp Stem Cells

[Cell Death & Disease] Dental pulp stem cells seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated mature human blood vessels invested with smooth muscle actin-positive mural cells.

Development of an Arteriolar Niche and Self-Renewal of Breast Cancer Stem Cells by Lysophosphatidic Acid/Protein Kinase D Signaling

[Communications Biology] Scientists indicated that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the lysophosphatidic acid/protein kinase D -CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.

Impairing Flow-Mediated Endothelial Remodeling Reduces Extravasation of Tumor Cells

[Scientific Reports] The authors aimed at dissecting the cellular and molecular mechanisms driving blood flow-dependent endothelial remodeling. Transcriptomic analysis of endothelial cells revealed that blood flow enhanced VEGFR signaling.

Genetic Engineering of Porcine Endothelial Cell Lines for Evaluation of Human-to-Pig Xenoreactive Immune Responses

[Scientific Reports] A porcine endothelial cell was characterized and immortalized for genetic modification. Five genes including GGTA1, CMAH, β4galNT2, SLA-I α chain, and β2-microglobulin that are responsible for the production of major xenoantigens were sequentially disrupted in immortalized porcine endothelial cells using CRISPR/Cas9 technology.

Hemocompatible L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs of Perforin Inhibitors Can Accumulate into the Pancreas and Alleviate Inflammation-Induced Apoptosis

[Chemico-Biological interactions] The effects of prodrug 1 were studied in lipopolysaccharide-induced in vitro and in vivo apoptosis and pancreatitis models by determining the cellular apoptotic levels with human umbilical vein endothelial cells and pancreatic caspase-3/-7 activity in mice.

Endothelial Cell Mechanics and Blood Flow Forces in Vascular Morphogenesis

[Seminars in Cell & Developmental Biology] Scientists discuss the cellular and molecular mechanisms involved in vascular network formation and how these intrinsic mechanisms are influenced by hemodynamic forces provided by pressurized blood flow.

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