Cholestatic and non-alcoholic fatty liver disease share several key pathophysiological mechanisms which can be targeted by novel therapeutic concepts that are currently developed for both areas.
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
The authors suggested that KFP-1, a novel calcium-binding peptide, bound extracellular calcium ions and entered Caco-2 and IEC-6 cells, and promoted calcium uptake through TRPV6 calcium channels.
[Molecular Nutrition & Food Research]
[zotpress userid=” items=’HVMTQ8E3′ style=’apa’ cite=’yes’]
The authors summarize recent advances in the field of bile acid signaling, studies of inflamed gut microbiome, and the therapeutic potential of bile acids in the context of inflammatory bowel disease.
[International Journal of Molecular Sciences]
[zotpress userid=” items=’3J7SNXE4′ style=’apa’ cite=’yes’]
Using a Drosophila intestinal model, scientists found that tumor cells outcompeted nearby enterocytes by influencing cell adhesion and contractility.
[zotpress userid=’7992332′ items=’HRF7L3V8′ style=’apa’ cite=’yes’]
The authors determined that 14-3-3σ expression was significantly downregulated in primary human colorectal cancer when compared with adjacent normal colonic tissue in patient samples. Downregulation of 14-3-3σ in primary colorectal cancers was significantly associated with p53 mutation, increasing tumor stage, distant metastasis, and poor patient survival.
[zotpress userid=’7992332′ items=’UWWDLLDN’ style=’apa’ cite=’yes’]
Neutrophil extracellular traps treatment induced intestinal epithelial monolayer barrier disruption and endoplasmic reticulum (ER) stress activation in a dose-dependent manner in vitro, and ER stress inhibition markedly attenuated intestinal apoptosis and tight junction injury.
[Cell Death & Disease]
[zotpress userid=” items=’5AJVJIRK’ style=’apa’ cite=’yes’]
Investigators showed that the intestine-enriched miR-802 was a central regulator of intestinal epithelial cell proliferation, Paneth cell function, and enterocyte differentiation.
[zotpress userid=” items=’ZS7GUDF7′ style=’apa’ cite=’yes’]
Scientists used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1- and -2-encoded type 3 secretion systems
[zotpress userid=” items=’M5Q4TD9X’ style=’apa’ cite=’yes’]
Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.
[Stem Cell Research & Therapy]
[zotpress userid=” items=’HNSNF8PP’ style=’apa’ cite=’yes’]
The authors found that LINGO3 was broadly expressed on human enterocytes and sparsely on discrete cells within the crypt niche, that contained sintestinal stem cells.
[Scandinavian Journal of Gastroenterology]
[zotpress userid=” items=’D5JNXRZV’ style=’apa’ cite=’yes’]
Researchers characterized intestinal goblet cells (GCs) expression diversity and defined how a specific GC subtype, localized in the intercrypt surface epithelium, functionally contributed to the formation of the mucus barrier.
[zotpress userid=’6445212′ items=’TNK2ZVJ3′ style=’apa’ cite=’yes’]