IL-22 Promotes the Formation of a MUC17 Glycocalyx Barrier in the Postnatal Small Intestine during Weaning

Ileal organoids consisted predominantly of enterocytes interspersed with Muc2-expressing goblet cells, recapitulating in vivo epithelial cell organization
[Cell Reports]
Layunta, E., Jäverfelt, S., Dolan, B., Arike, L., & Pelaseyed, T. (2021). IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports, 34(7). https://doi.org/10.1016/j.celrep.2021.108757 Cite
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Glycolipid-Dependent and Lectin-Driven Transcytosis in Mouse Enterocytes

Investigators provide evidence for a function of the glycolipid-lectin mechanism in transcytosis across enterocytes in the mouse intestine.
[Communications Biology]
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Epithelial Response to IFN-γ Promotes SARS-CoV-2 Infection

Using primary epithelial organoids from human colon, researchers explored how the central antiviral mediator IFN‐γ, which is elevated in COVID‐19, affected epithelial cell differentiation, ACE2 expression, and susceptibility to infection with SARS‐CoV‐2.
[EMBO Molecular Medicine]
Heuberger, J., Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M., Schmuck, R., Mollenkopf, H.-J., Brinkmann, V., Tacke, F., Osterrieder, N., & Sigal, M. (2021). Epithelial response to IFN-γ promotes SARS-CoV-2 infection. EMBO Molecular Medicine, n/a(n/a), e13191. https://doi.org/10.15252/emmm.202013191 Cite
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Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies

Researchers established an in vitro differentiation procedure to generate matured small intestinal cells mimicking human small intestine from human-induced pluripotent stem cells.
[Stem Cell Reports]
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Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies

Scientists demonstrated the generation of enterocyte-like cells by culturing human iPSC-derived intestinal progenitor cells on a collagen vitrigel membrane.
[Stem Cell Reports]
Yoshida, S., Honjo, T., Iino, K., Ishibe, R., Leo, S., Shimada, T., Watanabe, T., Ishikawa, M., Maeda, K., Kusuhara, H., Shiraki, N., & Kume, S. (2021). Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.12.017 Cite
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Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review

Scientists assessed the current literature detailing the effects of ω-3 polyunsaturated fatty acids (PUFAs) on epithelial cells. Marine-derived ω-3 PUFAs, eicosapentanoic acid and docosahexanoic acid, as well as plant-derived alpha-linolenic acid, are incorporated into intestinal epithelial cell membranes, prevent changes to epithelial permeability, inhibit the production of pro-inflammatory cytokines and eicosanoids and induce the production of anti-inflammatory eicosanoids and docosanoids.
[Foods]
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Proteomics Analysis of Human Intestinal Organoids during Hypoxia and Reoxygenation as a Model to Study Ischemia-Reperfusion Injury

Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation.
[Cell Death & Disease]
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Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases

Scientists investigated the impact of chemotherapy on the tumor immune microenvironment. They treated human liver metastases slices with 5-fluorouracil plus either irinotecan or oxaliplatin, then performed single-cell transcriptome analyses.
[Cell Reports Medicine]
Jabbari, N., Kenerson, H. L., Lausted, C., Yan, X., Meng, C., Sullivan, K. M., Baloni, P., Bergey, D., Pillarisetty, V. G., Hood, L. E., Yeung, R. S., & Tian, Q. (2020). Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases. Cell Reports Medicine, 1(9). https://doi.org/10.1016/j.xcrm.2020.100160 Cite
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Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine

Scientists showed that in Drosophila intestine autophagy lowered the sensitivity of differentiated enterocytes to reactive oxygen species that were produced in response to commensal bacteria.
[Developmental Cell]
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Cannabinoid Receptor Activation on Hematopoietic Cells and Enterocytes Protects against Colitis

Clinical parameters of colitis were assessed by colonoscopy, histology, flow cytometry and detection of serum biomarkers; single-cell RNA sequencing and qRT-PCR were used to evaluate the effects of cannabinoids on enterocytes.
[Journal of Crohns & Colitis]
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mtDNA-STING Pathway Promotes Necroptosis-Dependent Enterocyte Injury in Intestinal Ischemia Reperfusion

Researchers found that mitochondrial DNA (mtDNA)-mediated STING signaling triggered necroptosis through synergistic IFN and TNF-α signaling in primary IECs.
[Cell Death & Disease]
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