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enterocytes

Vitamin D3 Suppresses Intestinal Epithelial Stemness via ER Stress Induction in Intestinal Organoids

[Stem Cell Research & Therapy] Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.

Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System

[mBio] Scientists used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1- and -2-encoded type 3 secretion systems

LINGO3 Regulates Mucosal Tissue Regeneration and Promotes TFF2 Dependent Recovery from Colitis

[Scandinavian Journal of Gastroenterology] The authors found that LINGO3 was broadly expressed on human enterocytes and sparsely on discrete cells within the crypt niche, that contained sintestinal stem cells.

An Intercrypt Subpopulation of Goblet Cells Is Essential for Colonic Mucus Barrier Function

[Science] Researchers characterized intestinal goblet cells (GCs) expression diversity and defined how a specific GC subtype, localized in the intercrypt surface epithelium, functionally contributed to the formation of the mucus barrier.

Immune Modulation Mediated by Extracellular Vesicles of Intestinal Organoids Is Disrupted by Opioids

[Mucosal Immunology] Researchers showed that extracellular vesicles isolated from mouse and human intestinal organoids modulated inflammatory responses of various immune cells including mouse bone-marrow derived-macrophages, dendritic cells, microglia cells, and human monocytes.

Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

[American Journal of Physiology-Cell Physiology] Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.

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