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enterocytes

Signaling Pathways in Intestinal Homeostasis and Colorectal Cancer: KRAS at Centre Stage

[Cell Communication and Signaling] Scientists summarize the signaling pathways contributing to intestinal cell fates and homeostasis functions, focusing on intestinal stem cell proliferation, cell junction formation, remodeling, hypoxia, the impact of intestinal microbiota, the immune system, inflammation, and metabolism.

Culture and Differentiation of Rabbit Intestinal Organoids and Organoid-Derived Cell Monolayers

[Scientific Reports] The authors report a robust protocol for the isolation, maintenance and differentiation of rabbit small intestinal organoids and organoid-derived cell monolayers.

Murine Astrovirus Tropism for Goblet Cells and Enterocytes Facilitates an IFN-λ Response In Vivo and in Enteroid Cultures

[Mucosal Immunology] The authors describe a platform to cultivate muAstV using air–liquid interface cultures derived from mouse enteroids, which support apical infection and release.

SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids

[International Journal of Molecular Sciences] Researchers describe the basic virology and pathogenesis of SARS-CoV-2, highlighting how stem cell technology and organoids can contribute to the understanding of SARS-CoV-2 cell tropisms

IL-22 Promotes the Formation of a MUC17 Glycocalyx Barrier in the Postnatal Small Intestine during Weaning

[Cell Reports] Ileal organoids consisted predominantly of enterocytes interspersed with Muc2-expressing goblet cells, recapitulating in vivo epithelial cell organization

Glycolipid-Dependent and Lectin-Driven Transcytosis in Mouse Enterocytes

[Communications Biology] Investigators provide evidence for a function of the glycolipid-lectin mechanism in transcytosis across enterocytes in the mouse intestine.

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