The Onset, Development and Pathogenesis of Severe Neutrophilic Asthma

Scientists discuss the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma.
[Immunology and Cell Biology]
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Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.
[Journal of Clinical Investigation]
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An Immunologically Active, Adipose-Derived Extracellular Matrix Biomaterial for Soft Tissue Reconstruction: Concept to Clinical Trial

Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.
[NPJ Regenerative Medicine]
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Meteorin-β/Meteorin Like/IL-41 Attenuates Airway Inflammation in House Dust Mite-Induced Allergic Asthma

Increased Metrnβ effectively blocked the development of airway hyperreactivity and decreased inflammatory cell airway infiltration and type 2 cytokine production, which was associated with downregulated dendritic-mediated adaptive immune responses.
[Cellular & Molecular Immunology]
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Remote Immune Processes Revealed by Immune-Derived Circulating Cell-Free DNA

The authors characterized cell free DNA released from specific immune cell types in healthy individuals, cross sectionally and longitudinally.
[eLife]
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Acute Myeloid Leukemia Maturation Lineage Influences Residual Disease and Relapse Following Differentiation Therapy

Researchers indicated that relapse can originate from therapy-resistant mature acute myeloid leukemia cells, and suggested differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome.
[Nature Communications]
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Landscape of Hopx Expression in Cells of the Immune System

Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.
[Heliyon]
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A CIBERSORTx-Based Immune-Cell Scoring System Could Independently Predict Prognosis of Myelodysplastic Syndrome Patients

The authors adopted CIBERSORTx to estimate the relative fractions of 22 subtypes of immune cells in the bone marrow of 316 myelodysplastic syndrome patients and correlated the results with clinical outcomes.
[Blood Advances]
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Eosinophil Extracellular Traps Drive Asthma Progression through Neuro-Immune Signals

Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients.
[Nature Cell Biology]
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CCL11 Exacerbates Colitis and Inflammation-Associated Colon Tumorigenesis

Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.
[Oncogene]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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