Researchers examined the roles of group 2 innate lymphoid cells (ILC2s) in amebic liver abscesses formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5.
Researchers characterized the gastric mucosal inflammatory response associated with gastric MALT lymphoma (GML) and identified APRIL-producing cells in two model systems: an APRIL transgenic mouse model of GML induced by Helicobacter infection and human gastric biopsy samples from Helicobacter pylori-infected GML patients.
Researchers report that traditional, hematopoietic stem cell-derived myeloid cells in the adult lung, peripheral blood, and bone marrow also depend on interleukin 7 receptor expression.
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Investigators evaluated the effects of an anti-Siglec-8 monoclonal antibody in non-allergic disease models of experimental cigarette-smoke-induced chronic obstructive pulmonary disease and bleomycin-induced lung injury in Siglec-8 transgenic mice.
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Schanin, J., Gebremeskel, S., Korver, W., Falahati, R., Butuci, M., Haw, T. J., Nair, P. M., Liu, G., Hansbro, N. G., Hansbro, P. M., Evensen, E., Brock, E. C., Xu, A., Wong, A., Leung, J., Bebbington, C., Tomasevic, N., & Youngblood, B. A. (2020). A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-00336-9 Cite
Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
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Scientists report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease.
[Cell Reports Medicine]
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Rodriguez, L., Pekkarinen, P. T., Lakshmikanth, T., Tan, Z., Consiglio, C. R., Pou, C., Chen, Y., Mugabo, C. H., Nguyen, N. A., Nowlan, K., Strandin, T., Levanov, L., Mikes, J., Wang, J., Kantele, A., Hepojoki, J., Vapalahti, O., Heinonen, S., Kekäläinen, E., & Brodin, P. (2020). Systems-level immunomonitoring from acute to recovery phase of severe COVID-19. Cell Reports Medicine, 0(0). https://doi.org/10.1016/j.xcrm.2020.100078 Cite
Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.
[Nature Reviews Cancer]
The authors showed that adipose tissue eosinophils undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice.
Investigators present an international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis.
[American Journal of Respiratory and Critical Care Medicine]
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Moiseev, S., Bossuyt, X., Arimura, Y., Blockmans, D., Csernok, E., Damoiseaux, J., … Cohen Tervaert, J. W. (2020). International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202005-1628SO Cite
Investigators examined the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging.
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Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
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