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eosinophils

Pirfenidone Exacerbates Th2-Driven Vasculopathy in a Mouse Model of SSc-ILD

[European Respiratory Journal] Pirfenidone treatment attenuated pulmonary remodelling in the bleomycin-model, but aggravated pulmonary inflammation, fibrosis, and vascular remodelling in Fra-2 TG mice.

NF-κB Perturbation Reveals Unique Immunomodulatory Functions in Prx1+ Fibroblasts That Promote Development of Atopic Dermatitis

[Science Translational Medicine] Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.

The Onset, Development and Pathogenesis of Severe Neutrophilic Asthma

[Immunology and Cell Biology] Scientists discuss the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma.

Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

[Journal of Clinical Investigation] Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.

An Immunologically Active, Adipose-Derived Extracellular Matrix Biomaterial for Soft Tissue Reconstruction: Concept to Clinical Trial

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

Remote Immune Processes Revealed by Immune-Derived Circulating Cell-Free DNA

[eLife] The authors characterized cell free DNA released from specific immune cell types in healthy individuals, cross sectionally and longitudinally.

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