A CIBERSORTx-Based Immune-Cell Scoring System Could Independently Predict Prognosis of Myelodysplastic Syndrome Patients

The authors adopted CIBERSORTx to estimate the relative fractions of 22 subtypes of immune cells in the bone marrow of 316 myelodysplastic syndrome patients and correlated the results with clinical outcomes.
[Blood Advances]
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Eosinophil Extracellular Traps Drive Asthma Progression through Neuro-Immune Signals

Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients.
[Nature Cell Biology]
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CCL11 Exacerbates Colitis and Inflammation-Associated Colon Tumorigenesis

Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.
[Oncogene]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.
[Molecular Medicine Reports]
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Enhanced Eosinophil-Mediated Inflammation Associated with Antibody and Complement-Dependent Pneumonic Insults in Critical COVID-19

Scientists showed that critical COVID-19 was associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases.
[Cell Reports]
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Diesel Exhaust Particles Increase Nasal Symptoms and IL-17A in House Dust Mite-Induced Allergic Mice

Scientists investigated the effect of diesel exhaust particles (DEP) exposure on allergic rhinitis using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP.
[Scientific Reports]
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Tissue Signals Imprint Aiolos Expression in ILC2s to Modulate Type 2 Immunity

The authors interrogated the signatures of group 2 innate lymphoid cells from five tissues at the transcriptome and epigenetic level.
[Mucosal Immunology]
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Poly-L-Arginine Promotes Asthma Angiogenesis through Induction of FGFBP1 in Airway Epithelial Cells via Activation of the mTORC1-STAT3 Pathway

Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.
[Cell Death & Disease]
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Neutralization of IL-33 Modifies the Type 2 and Type 3 Inflammatory Signature of Viral Induced Asthma Exacerbation

Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection
[Respiratory Research]
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miR-100-5p in Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Mediates Eosinophilic Inflammation to Alleviate Atherosclerosis via the FZD5/Wnt/β-Catenin Pathway

Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.
[Acta Biochimica et Biophysica Sinica]
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