Tag results:
eosinophils
Immune Regulation News
Neutralization of IL-33 Modifies the Type 2 and Type 3 Inflammatory Signature of Viral Induced Asthma Exacerbation
[Respiratory Research] Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection
Umbilical & Placental Cell News
miR-100-5p in Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Mediates Eosinophilic Inflammation to Alleviate Atherosclerosis via the FZD5/Wnt/β-Catenin Pathway
[Acta Biochimica et Biophysica Sinica] Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.
Dermal Cell News
Blockade of the Co-Inhibitory Molecule PD-1 Unleashes ILC2-Dependent Antitumor Immunity in Melanoma
[Nature Immunology] Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
Pulmonary Cell News
Oleoylethanolamide Induces Eosinophilic Airway Inflammation in Bronchial Asthma
[Experimental and Molecular Medicine] To investigate the effect of OEA, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial (A549) cells.
Hematopoiesis News
The Twilight Zone: Plasticity and Mixed Ontogeny of Neutrophil and Eosinophil Granulocyte Subsets
[Seminars in Immunopathology] Researchers shed light on potential processes driving the plasticity and heterogeneity of granulocyte subsets and discuss the hematopoietic flexibility of granulocyte precursors in bone marrow and the adaptation of myeloid cells to local tissue microenvironments.
Human Immunology News
Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation
[British Journal of Immunology] Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.