eosinophils

[Mucosal Immunology] Researchers investigated the crosstalk between human eosinophils and esophageal epithelial cells. They reported that blood-derived eosinophils had prolonged survival when co-cultured with epithelial cells.

[Journal of Clinical Investigation] Researchers showed that UDP-glucose, a nucleotide sugar, was selectively released into the airways of allergen-sensitized mice upon their subsequent challenge with that same allergen.

[Allergy] Researchers hypothesized that a single administration of an adeno‐associated virus coding for an anti‐eosinophil monoclonal antibody that induces eosinophil clearance would treat on a persistent basis a murine model of eosinophilic esophagitis.

[Signal Transduction and Targeted Therapy] In adaptive immunity, effector T cells, especially Th17 cells, lead to the pathogenesis of cardiac fibrosis, including the distal fibrosis and scar formation. Cardiomyocytes protectors, Treg cells, inhibit reduce the inflammatory response, then directly trigger the regeneration of local progenitor cell via IL-10.

[npj Regenerative Medicine] Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction.

[Thorax] Researchers demonstrated that Rac1 is overactive in the airways of patients with severe asthma and is essential for airway smooth muscle cell proliferation.