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epilepsy

KIF5C Deficiency Causes Abnormal Cortical Neuronal Migration, Dendritic Branching, and Spine Morphology in Mice

[Pediatric Research] Investigators observed high KIF5C expression in neurons during the early developmental stage in mice and the human brain. Kif5c deficiency resulted in disturbed cortical neuronal migration, dendritic, and spine growth.

Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

[Brain Research Bulletin] Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.

Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain

[Trevena, Inc.] Trevena, Inc. announced it is advancing TRV045 into clinical development, following receipt of a notification from the US FDA that the study may proceed.

Human Stem Cell-Derived GABAergic Neurons Functionally Integrate into Human Neuronal Networks

[Scientific Reports] Researchers provided a proof-of-concept that human embryonic stem cell-derived neurons could integrate and modulate the activity of a human host neuronal network.

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome

[Molecular Neurobiology] Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.

SynGAP Research Fund Announces $308,000 Multidisciplinary Biomarker Grant to Boston Children’s Hospital

[SynGAP Research Fund] The SynGAP Research Fund announced grants to Drs. April Levin, Mustafa Sahin and Annapurna Poduri of Boston Children’s Hospital to advance SYNGAP1 biomarker characterization and genotype-phenotype analysis.

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