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epithelial cells

In Vitro and In Vivo Functions of T Cells Produced in Complemented Thymi of Chimeric Mice Generated by Blastocyst Complementation

[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.

Influence of Trichomonas vaginalis Macrophage Migration Inhibitory Factor on the Proliferation Activity of Prostate Epithelial Cell Line and Its Preliminary Mechanism

[andrology] The authors determined the influence of macrophage Trichomonas vaginalis macrophage migration inhibitory factor on prostate epithelial cells and its preliminary mechanism.

Differential Expression of HNF1A and HNF1A-AS1 in Colon Cancer Cells

[IUBMB Life] Scientists determined the epigenetic features of the HNF1A gene loci, and expression and cellular localization of HNF1A-AS1 RNA, HNF1A RNA, and HNF1A protein in colorectal cancer and normal colon epithelial cells.

PTPN2 Elicits Cell Autonomous and Non–Cell Autonomous Effects on Antitumor Immunity in Triple-Negative Breast Cancer

[Science Advances] Scientists explored the therapeutic potential of targeting PTPN2 in TNBC and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival.

Fibroblast Growth Factor Receptor Signaling Dysregulation and Targeting in Breast Cancer

[Open Biology] FGFR signaling on epithelial cells is affected by signals from the breast microenvironment, therefore increasing the possibility of breast developmental abnormalities or cancer progression.

Telomere Shortening Accelerates Tumor Initiation in the L2-IL1B Mouse Model of Barrett Esophagus and Emerges as a Possible Biomarker

[Oncotarget] Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus. The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach.

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