Tag results:

epithelial cells

Exosomal microRNAs Synergistically Trigger Stromal Fibroblasts in Breast Cancer

[Molecular Therapy-Nucleic Acids] The authors demonstrated that triple negative breast cancer cell-derived exosomes increased normal fibroblast collagen contraction and migration alongside cancer-associated fibroblasts molecular markers.

TLR2 and TLR7 Mediate Distinct Immunopathological and Antiviral Plasmacytoid Dendritic Cell Responses to SARS-CoV-2 Infection

[EMBO Journal] Via targeted deletion of virus-recognition innate immune pathways, scientists identified TLR7-MyD88 signaling as crucial for production of antiviral interferons, whereas TLR2 is responsible for the inflammatory IL-6 response.

Long Noncoding RNA CCAT2 Reduces Chemosensitivity to 5-Fluorouracil in Breast Cancer Cells by Activating the mTOR Axis

[Journal of Cellular and Molecular Medicine] The authors explored whether breast cancer cell drug sensitivity to 5-Fu was related to lncRNA CCAT2-regulated mTOR pathway.

Serotoninergic Receptor Ligands Improve Tamoxifen Effectiveness on Breast Cancer Cells

[BMC Cancer] Researchers investigated the effect of 10 serotoninergic receptor ligands on viability of MCF7, SKBR3 and MDA-MB231 breast cancer cells and focused on their potential ability to affect Tamoxifen responsiveness in ER+ cells.

EGFR Ligand Clustering on E2 Bionanoparticles for Targeted Delivery of Chemotherapeutics to Breast Cancer Cells

[Journal of the American Chemical Society] Researchers demonstrated approximately 3-fold higher doxorubicin internalization in inflammatory breast cancer cells compared to healthy breast epithelial cells, leading to targeted cell death at concentrations below the IC50 of free doxorubicin.

IRE1α Drives Lung Epithelial Progenitor Dysfunction to Establish a Niche for Pulmonary Fibrosis

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.

Popular