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epithelial cells

Neutrophil-Derived Extracellular Vesicles Promote Feed-Forward Inflammasome Signaling in Cystic Fibrosis Airways

[Journal of Leukocyte Biology] Researchers hypothesized that cystic fibrosis airway neutrophils contributed to chronic inflammation, in part, via the packaging of inflammasome-inducing signals in extracellular vesicles.

Ex Vivo Enzymatic Treatment Converts Blood Type A Donor Lungs into Universal Blood Type Lungs

[Science Translational Medicine] Investigators studied the safety and preclinical efficacy of using these enzymes to remove A antigen from human donor lungs using ex vivo lung perfusion.

Force Generation Machinery Is Exploited by Cancer Cells Promoting Tumor Progression via ECM Remodeling and Immunosuppression

[Biophysical Journal] Researchers found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen presenting cells, facilitating tumor progression.

The Oral Protease Inhibitor (PF-07321332) Protects Syrian Hamsters against Infection with SARS-CoV-2 Variants of Concern

[Nature Communications] The authors reported that PF-332 exerted equipotent in vitro activity against the four SARS-CoV-2 variants of concerns and that it could completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface.

Macrophages Connection: Aggressive Nanomechanical Phenotypes of Circulating Tumor Cells in Prostate Cancer

[Biophysical Journal] The authors showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.

Integrated Single-Cell Multiomics Analysis Reveals Novel Candidate Markers for Prognosis in Human Pancreatic Ductal Adenocarcinoma

[Cell Discovery] Researchers identified normal epithelial cells in the tumor lesion, which have euploid genomes, normal patterns of DNA methylation, and chromatin accessibility.

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