Integrating Longitudinal Clinical Laboratory Tests with Targeted Proteomic and Transcriptomic Analyses Reveal the Landscape of Host Responses in COVID-19

Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.
[Cell Discovery]
Tan, Y., Zhang, W., Zhu, Z., Qiao, N., Ling, Y., Guo, M., Yin, T., Fang, H., Xu, X., Lu, G., Zhang, P., Yang, S., Fu, Z., Liang, D., Xie, Y., Zhang, R., Jiang, L., Yu, S., Lu, J., … Chen, S. (2021). Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19. Cell Discovery, 7(1), 1–19. https://doi.org/10.1038/s41421-021-00274-1 Cite
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Structural Basis for SARS-CoV-2 Envelope Protein Recognition of Human Cell Junction Protein PALS1

To understand the structural basis for SARS-CoV-2 viral-host protein recognition, scientists used cryo-electron microscopy to determine a complex structure of the human cell junction protein PALS1 and SARS-CoV-2 viral envelope protein.
[Nature Communications]
Chai, J., Cai, Y., Pang, C., Wang, L., McSweeney, S., Shanklin, J., & Liu, Q. (2021). Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1. Nature Communications, 12(1), 3433. https://doi.org/10.1038/s41467-021-23533-x Cite
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Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ-on-a-Chip Vasculature

3D vascularized pancreatic adenocarcinoma tissue was microengineered in a tri-culture system composed of patient-derived pancreatic organoids, human fibroblasts, and endothelial cells on a perfusable platform, situated in a 96-well plate.
[Advanced Functional Materials]
Nakagami, H., Hayashi, H., Shimamura, M., Rakugi, H., & Morishita, R. (2021). Therapeutic vaccine for chronic diseases after the COVID-19 Era. Hypertension Research, 1–7. https://doi.org/10.1038/s41440-021-00677-3 Cite
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T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumours

Researchers showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., Karches, C. H., Heise, C., Kurzay, M., Larimer, B. M., Grassmann, S., Rapp, M., Nottebrock, A., Kruger, S., Tokarew, N., … Kobold, S. (2021). T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00737-6 Cite
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Human iPS Cells Engender Corneal Epithelial Stem Cells with Holoclone-Forming Capabilities

Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience]
Watanabe, S., Hayashi, R., Sasamoto, Y., Tsujikawa, M., Ksander, B. R., Frank, M. H., Quantock, A. J., Frank, N. Y., & Nishida, K. (2021). Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102688 Cite
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Single-Cell RNA Sequencing of Human Nail Unit Defines RSPO4 Onychofibroblasts and SPINK6 Nail Epithelium

Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
[Communications Biology]
Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
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Differential Localization of Serotoninergic System Elements in Human Amniotic Epithelial Cells

Researchers investigated the expression and distribution of the main components of the serotoninergic system in human amniotic tissue and in human amniotic epithelial cells in vitro, as an alternative model of early human embryo development.
[Biology of Reproduction]
Romero-Reyes, J., Vázquez-Martínez, E. R., Bahena-Alvarez, D., López-Jiménez, J., Molina-Hernández, A., Camacho-Arroyo, I., & Díaz, N. F. (2021). Differential localization of serotoninergic system elements in human amniotic epithelial cells†. Biology of Reproduction, ioab106. https://doi.org/10.1093/biolre/ioab106 Cite
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T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumors

Scientists showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
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Neutrophils and Influenza: A Thin Line between Helpful and Harmful

The authors provide an overview of neutrophil characteristics, their classic effector functions, as well as more recently described antibody-mediated effector functions.
[Viruses-Basel]
George, S. T., Lai, J., Ma, J., Stacey, H. D., Miller, M. S., & Mullarkey, C. E. (2021). Neutrophils and Influenza: A Thin Line between Helpful and Harmful. Vaccines, 9(6), 597. https://doi.org/10.3390/vaccines9060597 Cite
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RNF20 and RNF40 Regulate Vitamin D Receptor-Dependent Signaling in Inflammatory Bowel Disease

Scientists examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in inflammatory bowel disease (IBD) patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.
[Cell Death & Differentiation]
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Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery

The impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively.
[Marine Drugs]
Davoudi, Z., Peroutka-Bigus, N., Bellaire, B., Jergens, A., Wannemuehler, M., & Wang, Q. (2021). Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery. Marine Drugs, 19(5), 282. https://doi.org/10.3390/md19050282 Cite
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