epithelial cells

[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.

[Molecular Oncology] Targeting ubiquitin carboxyl-terminal hydrolase 28 (USP28) protein abundance at an early stage via inhibition of its activity is a feasible strategy for the treatment of early-stage lung tumors.

[Journal of Controlled Release] Researchers developed a formulation for pulmonary administration of siRNA to suppress SARS-CoV-2 replication in lung epithelial cells.

[Cell Reports] Scientists showed that during alveologenesis, Hedgehog-responsive PDGFRa(+) progenitors were a source of secreted trophic molecules that maintained a unique lung alveolar type 2 progenitor population.

[Science Signaling] In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos.

[iScience] The authors hypothesized that viral mimic-priming improved mesnchymal stem cells' abilities to rebalance the dysregulated immune responses in COVID-19.