epithelial cells

[Toxicology and Applied Pharmacology] The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.

[Nature Aging] The authors showed that histologically normal breast tissue from younger women who were susceptible to breast cancer, as a result of harboring a germline mutation in BRCA1, BRCA2or PALB2 genes, exhibited hallmarks of accelerated aging.

[Biophysical Reports] The author investigated the viscoelastic properties of basolateral membranes derived from polarized MDCK II epithelia in response to external deformation and compared them to living cells probed at the apical side.

[Cell Cycle] Scientists performed pooled CRISPR delivery with single-cell transcriptome analysis on the MIN6 cell line, a pancreatic β-cell line. They presented the single-cell RNA sequencing readout and demonstrated that the MIN6 cell line might develop genetic heterogeneity with increasing passage number based on GO and KEGG pathway analysis.

[Molecular Medicine Reports] The authors investigated whether phillygenin could inhibit inflammation and apoptosis of pulmonary epithelial cells by activating peroxisome proliferator‑activated receptor γ (PPARγ) signaling.

[Scientific Reports] The Hippo pathway regulates the proliferation of cancer cells, pluripotent stem cells, and epithelial cells through a cell–cell contact-dependent manner, however, it is unclear if cell density-dependent cell proliferation is a consistent feature in cardiac myocytes. Scientists used cultured human iPSC-derived cardiac myocytes as a model system to investigate this concept.