IL-17A-Producing T Cells Exacerbate Fine Particulate Matter-Induced Lung Inflammation and Fibrosis by Inhibiting PI3K/Akt/mTOR-Mediated Autophagy

Primary bronchial epithelial cells (mBECs) were extracted, and the expression of TGF signaling pathway‐, autophagy‐ and PI3K/Akt/mTOR signaling pathway‐related proteins in mBECs was detected by immunofluorescence assay and Western blot analysis.
[Journal of Cellular and Molecular Medicine]
Cong, L.-H., Li, T., Wang, H., Wu, Y.-N., Wang, S.-P., Zhao, Y.-Y., … Duan, J. (n.d.). IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15475 Cite
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Nitrative DNA Damage in Lung Epithelial Cells Exposed to Indium Nanoparticles and Indium Ions

Scientists examined 8-nitroG formation in A549 cultured human lung epithelial cells treated with indium compounds, including nanoparticles of indium oxide and indium-tin oxide, and indium chloride.
[Scientific Reports]
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Distal Lung Epithelial Progenitor Cell Function Declines with Age

Investigators compared the lungs of 3- and 22-month old mice. They examined the gross morphological changes in these lungs, the density and function of epithelial progenitor populations and the epithelial gene expression profile.
[Scientific Reports]

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Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype

Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
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Wnt/β‐Catenin Signaling Is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema

Researchers identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type II cells.
[Stem Cells]
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Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus to Initiate Autophagy during Infection

The authors stimulated cells and infected mice with M and FbaA mutants of M1 Group A Streptococcus strain SF370 or with purified M and FbaA proteins, and found that only FbaA protein was involved in autophagy induction.
[mBio]
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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human iPSCs in an organ-like environment, investigators generated functional engineered human mini-livers and performed transplantation in a rat model.
[Cell Reports]
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The Msi1-mTOR Pathway Drives the Pathogenesis of Mammary and Extramammary Paget’s Disease

Investigators identified MSI1 ectopic overexpression in basal epithelial cells of human Paget’s disease (PD) skin, and showed that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels.
[Cell Research]
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