epithelial cells

[Nature Communications] Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.

[Acta Pharmacologica Sinica] Alcohol dehydrogenase 1C (ADH1C) was first identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics, proteomics, metabonomics and in silico analysis.

[Science Translational Medicine] In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.

[Nature Communications] Investigators examined human airway epithelium infected with three different isolates of SARS-CoV-2 including the B.1.1.7 variant by transmission electron microscopy and tomography.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists mapped potential pathways for citrate carbons in the human prostate cancer metastasis cell lines LNCaP and VCaP, for which they first established that they secrete citrate.

[Science Translational Medicine] Scientists performed the basal-like breast cancers (BLBCs) tissue microarray–based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 abundance was associated with poor prognosis in BLBCs.