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Extracellular Matrix News
Human Immunology News
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
[Frontiers in Immunology] Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.
Cancer Stem Cell News
Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment
[Embo Journal] Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
Cancer Stem Cell News
BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling
[Journal of Immunology] lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
Cancer Stem Cell News
Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome
[Arthritis Research & Therapy] The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
Extracellular Matrix News
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix
[Circulation Research] Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
Extracellular Matrix News
A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice
[European Journal of Human Genetics] Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.