Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.
[Frontiers in Immunology]
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Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
[Embo Journal]
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BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling

lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
[Journal of Immunology]
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Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome

The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
[Arthritis Research & Therapy]
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A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
[European Journal of Human Genetics]
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Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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Drop-on-Demand Cell Bioprinting via Laser Induced Side Transfer (LIST)

Researchers showed that LIST-printed HUVECS present negligible loss of viability and maintain their abilities to migrate, proliferate and form intercellular junctions.
[Scientific Reports]
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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
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Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
[Molecular Therapy]
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Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels

Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
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