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Extracellular Matrix News
Extracellular Matrix News
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy
[Molecular Cell] The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
Endothelial Cell News
Drop-on-Demand Cell Bioprinting via Laser Induced Side Transfer (LIST)
[Scientific Reports] Researchers showed that LIST-printed HUVECS present negligible loss of viability and maintain their abilities to migrate, proliferate and form intercellular junctions.
Extracellular Matrix News
Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo
[Scientific Reports] Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
Extracellular Matrix News
Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels
[Nature Cell Biology] Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
Extracellular Matrix News
Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages
[Molecular Therapy] Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
Dermal Cell News
Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers
[Scientific Reports] The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.