extracellular matrix

[Science Advances] To probe the role of B cells in biomaterial scaffold response, scientists evaluated the B cell response to biomaterial materials implanted in a muscle wound using a biological ECM as a reference for a naturally derived material, and synthetic polyester polycaprolactone as a reference for a synthetic material.

[npj Parkinson's Disease] To detect potential effects of different glucose levels on gene expression, by RNA-seq researchers analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations.

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] A collagen-based, angle-ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling.

[Advanced Science] Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (ECM), which were further preserved in acellular cartilaginous ECM following mild, short-period decellularization.

[Advanced Drug Delivery Reviews] The authors outline hematopoietic stem cell (HSC) niche biology, review the role of the different classes of ECM molecules in the niche, and discuss matrix remodeling and the emerging importance of biophysics in HSC niche function.

[Scientific Reports] The contribution of select matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) to the progression of myocardial infarction and progressive sudden death was examined in Apoe-deficient mice with concomitant deletion of Mmp7, Mmp9, Mmp12, or Timp1 and relevant wild-type controls after 36-weeks high-fat feeding.