GDF11 Prevents the Formation of Thoracic Aortic Dissection in Mice: Promotion of Contractile Transition of Aortic SMCs

Researchers investigated the expression of GDF11 in thoracic aortic dissection and its effects on aortic smooth muscle cell phenotype transition.
[Journal of Cellular and Molecular Medicine]
Ren, K., Li, B., Liu, Z., Xia, L., Zhai, M., Wei, X., Duan, W., & Yu, S. (n.d.). GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16312 Cite
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A Thermo-Responsive Collagen-Nanocellulose Hydrogel for the Growth of Intestinal Organoids

Scientists investigated collagen-nanocellulose hydrogels as a thermo-responsive matrix for the formation and growth of intestinal organoids.
[Materials Science and Engineering: C]
Curvello, R., Alves, D., Abud, H. E., & Garnier, G. (2021). A thermo-responsive collagen-nanocellulose hydrogel for the growth of intestinal organoids. Materials Science and Engineering: C, 112051. https://doi.org/10.1016/j.msec.2021.112051 Cite
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Functional Tissue-Engineered Bone-Like Graft Made of a Fibrin Scaffold and TG2 Gene-Modified EMSCs for Bone Defect Repair

A novel biofunctional live tissue-engineered bone-like graft was designed and constructed using a fibrin scaffold loaded with TG2 gene-modified ectomesenchymal stem cells (TG2-EMSCs) derived from nasal respiratory mucosa for bone defect repair.
[NPG Asia Materials]
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Computational and Experimental Characterization of the Novel ECM Glycoprotein SNED1 and Prediction of its Interactome

Pathway analysis of the predicted SNED1 interactome further revealed that it may contribute to signaling through cell surface receptors, such as integrins, and participate in the regulation of ECM organization and developmental processes.
[Biochemical Journal]
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Global Proteomic Analysis of Extracellular Matrix in Mouse and Human Brain Highlights Relevance to Cerebrovascular Disease

Scientists developed an approach to extract the cerebrovascular extracellular matrix from mouse and human post-mortem normal brain tissues.
[Journal of Cerebral Blood Flow and Metabolism]
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EPB41L5 Controls Podocyte Extracellular Matrix Assembly by Adhesome-Dependent Force Transmission

Scientists showed by analysis of in vitro and in vivo models that a loss of the podocyte-specific FERM-domain protein EPB41L5 results in impaired extracellular matrix assembly.
[Cell Reports]
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Inhibition of ERK 1/2 Kinases Prevents Tendon Matrix Breakdown

The authors showed that extracellular-signal regulated kinase (ERK) 1/2 were highly phosphorylated in mechanically unloaded tendon fascicles in a vascular niche-dependent manner.
[Scientific Reports]
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Elastin-Specific MRI of Extracellular Matrix-Remodeling following Hepatic Radiofrequency-Ablation in a VX2 Liver Tumor Model

To investigate the potential of an elastin-specific MR agent for the assessment of extracellular matrix remodeling in the periablational rim following radiofrequency ablation in a VX2 rabbit liver tumor-model, twelve New-Zealand-White-rabbits were implanted in the left liver lobe with VX2 tumor chunks from donor animals.
[Scientific Reports]
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Optimization of Extracellular Matrix Production from Human Induced Pluripotent Stem Cell‐Derived Fibroblasts for Scaffold Fabrication for Application in Wound Healing

Researchers optimized fibroblasts derived from iPS cell matrix production by boosting matrix deposition, without affecting its composition.
[Journal of Biomedical Materials Research Part A]
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Engineering High-Yield Biopolymer Secretion Creates an Extracellular Protein Matrix for Living Materials

Scientists designed a two-strain bacterial system that self-synthesizes and structures a synthetic extracellular matrix of proteins. They engineered Caulobacter crescentus to secrete an extracellular matrix protein composed of an elastin-like polypeptide hydrogel fused to supercharged SpyCatcher.
[mSystems]
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The Extracellular Matrix Complexity of Idiopathic Epiretinal Membranes and the Bilaminar Arrangement of the Associated Internal Limiting Membrane in the Posterior Retina

The authors studied the composition of the internal limiting membrane of the retina, the extracellular matrix of idiopathic epiretinal membranes, and the relationships occurring between the two membranes.
[Graefe’s Archive for Clinical and Experimental Ophthalmology]
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