extracellular matrix

[Krystal Biotech, Inc.] Jeune Aesthetics, Inc. announced positive proof-of-concept efficacy data from Cohort 2 of the PEARL-1 study of KB301, Jeune Aesthetics’ lead candidate for the treatment of aesthetic skin conditions. KB301 leverages Krystal’s proprietary gene delivery platform to restore protein production and rebuild the underlying ECM structure.

[Biomaterials] Tthe culture and expansion of human cholangiocyte organoids in liver extracellular matrix-derived hydrogels is described. These hydrogels supported proliferation of cholangiocyte organoids and maintain the cholangiocyte-like phenotype.

[Cell Reports] To establish a genome-wide loss-of-function screening for heterozygous mutations, the authors fused normal haploid hESCs with a library of mutant haploid hESCs.

[Nature Communications] Researchers demonstrated that gastrointestinal tissue-derived ECM hydrogels were suitable substitutes for Matrigel in gastrointestinal organoid culture.

[Nature Immunology] By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, scientists showed that preexisting matrix was transferred across organs into wounds in various injury models.

[Communications Biology] The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.